About this trial
This study aims to investigate the relationship between diet and the microbiota-gut-brain axis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Be able to give written informed consent.
Be between 18 and 50 years of age.
Have a body mass index (BMI) between 18.5-29.9 Kg/m2.
Be in generally good health as determined by the investigator.
Disqualifiers
Are less than 18 and greater than 50 years of age.
Have a BMI below 18.5 or above 29.9 Kg/m2.
Have a significant acute or chronic coexisting illness [cardiovascular, gastrointestinal (GI) [to include functional GI disorders, inflammatory bowel disease, coeliac disease, lactose intolerance, food allergies], immunological, psychiatric [to include formal or as determined by MINI Psychiatric interview, diagnosis of current major depression, anxiety disorder, bipolar spectrum disorder, schizophrenia, other DSM-IV Axis I disorder], neurodevelopmental disorders, immunological, metabolic disorders [to include type I or II diabetes], or any condition which contraindicates, in the investigators judgement, entry to the study.
Have a condition or taking a medication that the investigator believes would interfere with the objectives of the study, pose a safety risk, or confound the interpretation of the study results; all psychoactive medications [to include anxiolytics, antipsychotics, antidepressants, anticonvulsants, centrally acting corticosteroids, and opioid pain relievers), laxatives, enemas, antibiotics, anti-coagulants, over-the counter non-steroidal anti-inflammatories (NSAIDS). Subjects should have a wash-out period of 4 weeks.
Trial population
Healthy adult volunteers consuming varying amounts of dietary fibre.
Trial design
Other
Cross-sectional
Treatments tested in this trial
Dietary fibre
Other interventionHabitual dietary consumption from a variety of foods will be assessed using 7-day food logs entered by the participant and assessed for accuracy by a dietitian.
Treatment groups
Trial outcomes
Primary outcomes
Trait stress/mood: self-report
Self-report questionnaires
Trait stress/mood: hypothalamic-pituitary-adrenal axis activity
Cortisol from saliva samples
Responses to acute stress: self-report
Self-report questionnaires
Responses to acute stress: hypothalamic-pituitary-adrenal axis activity
Cortisol from saliva samples
Secondary outcomes
Cognitive performance: working memory
Spatial Working Memory
Cognitive performance: episodic memory
Modified Rey Auditory Verbal Learning Test (ModRey)
Cognitive performance: decision making
Iowa Gambling Task
Cognitive performance: emotional inhibition
Emotional stroop
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