The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol in Cases of Missed Abortion

ConditionLetrozole

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexFemale

Age18-45

SponsorCairo University

About this trial

The aim is to evaluate the effect of letrozole pretreatment on the induction time during medical evacuation using misoprostol in women diagnosed with missed abortion, and to compare its efficacy and safety to misoprostol alone.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Women aged 18 - 45 years.

Diagnosed with missed abortion confirmed by ultrasound (absent fetal heartbeat and/or no embryonic development).

Gestational age ≤ 12 weeks based on last menstrual period

Hemoglobin levels >10 g/dL.

Disqualifiers

Incomplete abortion, inevitable abortion, or threatened miscarriage.

Suspected ectopic pregnancy and molar pregnancy.

History of allergy or contraindication to misoprostol or letrozole.

Coagulopathy or use of anticoagulant medications.

Trial design

Design model

Parallel

Treatments tested in this trial

Intervention Group: letrozole followed by misoprostol
Procedure/Surgery
Group A (Intervention Group) will receive letrozole followed by misoprostol.
Control Group: misoprostol only
Procedure/Surgery
Group B (Control Group) will receive misoprostol only, without prior letrozole pretreatment

Treatment groups

74 Participants

are divided into 2 treatment groups

Group A: Intervention Group: letrozole followed by misoprostolExperimental treatment 1 intervention

Group B: Control Group: misoprostol onlyActive comparator 1 intervention

Trial outcomes

Primary outcomes

Time of complete uterine evacuation

Time from misoprostol administration to complete uterine evacuation

Time frame

one week following Misoprostol administration

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: