Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCapital Medical University
About this trial
This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation after emergency endovascular therapy (EVT).
Eligibility criteria
Qualifiers
Aged 18 years or over.
Clinical diagnosis of large vessel occlusion acute ischemic stroke.
Emergency endovascular treatment was performed within 24 hours of stroke onset.
12-lead ECG recording
Disqualifiers
Atrial fibrillation due to reversible causes (e.g. thyrotoxicosis, pericarditis, recent surgery, or myocardial infarct).
Known allergy or intolerance to both factor Xa inhibitors and direct thrombin inhibitors;
Definite indication for vitamin K antagonist (VKA) treatment (e.g. mechanical heart valve, valvular atrial fibrillation);
Severe renal impairment (defined as creatinine exceeding 1.5 times of the upper limit of normal range) and significant hepatic dysfunction (defined as ALT or AST > twice the upper limit of normal range) ;
Trial design
Treatments tested in this trial
- Early anticoagulation
- Delayed anticoagulation
Treatment groups
438 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov