To Compare the Effects of Oxytocin and Carbetocin on Intraoperative Hemodynamic Changes in Cesarean Section Surgeries.

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorYuzuncu Yil University

About this trial

To compare the effects of oxytocin and carbetocin, used as uterotonics in elective caesarean section surgeries, in terms of intraoperative hemodynamic changes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients scheduled for caesarean sections

Between 18-40 years

ASA I-II group

Those who will undergo general anesthesia

Disqualifiers

Those who prefer spinal or epidural anesthesia

Those who are outside the age range of 18-40

Those who are ASA III and above

Those with HT, DM, cardiac and respiratory diseases

Trial design

Design model

Parallel

Treatments tested in this trial

  • Group-C

    Procedure/Surgery

    100 iu carbetosin administered to carbetocin group

  • Group-O

    Procedure/Surgery

    In cesarean surgery, 5 IU of oxytocin will be administered after the baby delivered.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Oxytocin (Group-O)Active comparator 1 intervention
Group B: Carbetocin (Group-C)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Uterine tonus

The effect of carbetocin on uterine tone will be evaluated by the surgical team using a numerical scoring scale between 0-10. A score of 0 will indicate atony, and a score of 10 will indicate full contraction.

Time frame
For 30 minutes after carbetocin administration.
2

Additional uterotonic drug requirement

If the uterine tone is 7 or below, the surgical team will perform uterine massage, and in patients who do not see a sufficient increase in uterine tone, an additional uterotonic, 0.2 mg methylergonavine (Methyl ampoule 0.2 mg/ml) will be administered IM by the anesthesia team and recorded.

Time frame
For 30 minutes after carbetocin administration.

Secondary outcomes

1

Intraoperative bleeding

Total intraoperative bleeding was recorded by calculating and estimating the aspirator volume, pad-sponge-compress count and surgical area.

Time frame
from drug administration to the end of surgery.
2

Mean Blood Pressure

Mean blood pressure will be measured every 5 minutes intraoperatively using a noninvasive method.

Time frame
Intraoperatively every 5 minutes
3

Heart Rate

Heart rate will be measured every 5 minutes intraoperatively using a noninvasive method.

Time frame
Intraoperatively every 5 minutes

Other outcomes

Sponsors and contacts

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