The goal of this clinical trial is to test the efficacy of a transdiagnostic Internet-delivered interventions for Romanian adolescents with anxiety and/ or depression. The main questions it aims to answer are:
* What is the clinical efficacy of the Internet-delivered intervention? * How accurate is the prediction model in predicting who will respond to treatment? Participants will undergo non-invasive fMRI to measure variability in brain signal as a proxy of the neural systems' adaptability before receiving the intervention, then they will be allocated either to the Internet-delivered intervention or control group.
elevated symptoms of anxiety or depression/ internalizing problems (T score> 60) at intake (based on Youth self-report completed by adolescents)
primary diagnosis of an anxiety/depressive disorder based on DSM-5 criteria according to ADIS-5-C/P interview
age 13-17
able to read and understand Romanian language
severe mental disorder (psychosis, severe depression, bipolar disorder, based on clinical interview)
any condition that interferes with the protocol implementation (e.g., physical illness or sensory impairment that interferes with behavioral tasks such as exposure, behavioral activation, unavailable for the next 3 months),
active suicidal ideation (assessed by child psychiatrist during clinical interview) in the last month
currently following CBT/ psychotherapy for anxiety/depression, in the last 6 months
Parallel
Transdiagnostic Internet-delivered intervention
BehavioralThe intervention consists of 8 modules based on Rational emotive therapy, delivered via 8 weeks.
Internalizing problems
Change from baseline in internalizing problems. Revised Children's Anxiety and Depression Scale (RCADS) completed by adolescents.
Clinical diagnosis
Change in DSM-5 Anxiety and Depressive Disorder Diagnoses in Accordance with Anxiety Disorders Interview Schedule for the DSM-5, Child and Parent Versions (ADIS-5-C/P) Clinical Diagnosis
Global functioning
Children's Global Assessment Scale (C-GAS)
Severity
Clinical Global Impression Scale - Severity
Improvement
Clinical Global Impression Scale - Improvement
Click on the lead sponsor to view all of their trials.
