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Treating Intrabony Defect With MINST VS MINST Extended PRF

ConditionPeriodontal Intrabony Defects
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCairo University

About this trial

This study evaluates a minimally invasive non-surgical technique (MINST) for treating periodontal intrabony defects, with or without the addition of Extended Platelet-Rich Fibrin (e-PRF). The goal is to determine which approach provides better bone regeneration and gum healing.

Study Procedures

Control Group:

Local anesthesia by infiltration at the treatment site

Instrumentation of the root surface up to the bottom of the periodontal pocket

Efforts are made to minimize trauma to soft tissues and interdental papilla using subpapillary access

Cleaning is performed using piezo-electric devices with delicate tips, avoiding aggressive root smoothing or gingival curettage

3-4× magnification loupes are used to improve precision

Intervention Group:

All the above procedures

Followed by injection of e-PRF, a preparation derived from the patient's own blood

Blood is collected in 4 mL tubes and centrifuged at 700 g for 8 minutes

The platelet-poor plasma is heated to create an albumin gel

The remaining buffy coat (rich in platelets and growth factors) is mixed with the cooled albumin gel to form Alb-PRF, which is applied to the defect

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Extended Platelet-Rich Fibrin (e-PRF)

    Biological/Vaccine

    Autologous extended platelet-rich fibrin (e-PRF) prepared from the participant's peripheral blood. Whole blood is centrifuged to obtain liquid platelet-rich fibrin, while the platelet-poor plasma is heated to form denatured albumin gel. The cooled albumin gel is mixed with the liquid platelet-rich fibrin to produce e-PRF, which is applied into the periodontal intrabony defect immediately after completion of the MINST procedure

  • Modified Minimally Invasive Non-Surgical Technique (MINST)

    Procedure/Surgery

    Modified minimally invasive non-surgical periodontal therapy performed under local anesthesia using piezoelectric ultrasonic instruments with thin tips and magnification loupes. The procedure aims to thoroughly debride the periodontal pocket while minimizing soft tissue trauma and preserving root cementum by avoiding intentional root surface smoothing and gingival curettage.

Treatment groups

48 Participants
are divided into 2 treatment groups
Group A: MINST AloneActive comparator 1 intervention
Group B: MINST + Extended Platelet-Rich Fibrin (e-PRF)Experimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Change in Probing Depth (PD)

Change in periodontal probing depth (PD), measured in millimeters using a UNC-15 periodontal probe with a standardized probing force. Measurements are obtained using a patient-specific acrylic stent to ensure reproducibility.

Time frame
Baseline and 6 months after treatment

Secondary outcomes

1

Clinical Attachment Level (CAL)

Time frame
Baseline, 3 months, and 6 months after treatment
2

Change in Gingival Recession (GR) measured using a UNC-15 periodontal probe

Time frame
Baseline, 3 months, and 6 months after treatment
3

Change in Radiographic Intrabony Defect Depth measured using standardized periapical radiographs and ImageJ software

Time frame
Baseline and 6 months after treatment
4

Patient Satisfaction (VAS)

0 indicates no pain or discomfort and 10 indicates the worst imaginable pain or discomfort.

Time frame
During the first postoperative week after treatment

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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