Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-65
SponsorTanta University

About this trial

This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged from 21 to 65 years.

Both sexes.

American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.

Schedule for elective umbilical hernia surgery under general anesthesia.

Disqualifiers

ASA Ⅲ or Ⅳ.

Patients with metabolic abnormalities, e.g., diabetes mellitus.

Patients receiving corticosteroids.

History of allergies to local anesthetics.

Trial design

Design model

Parallel

Treatments tested in this trial

  • General anesthesia

    Other intervention

    Patients will receive general anesthesia only.

  • External oblique and rectus abdominis plane (EXORA) block

    Other intervention

    Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Group IActive comparator 1 intervention
Group B: Group ⅡExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Neuroendocrine stress response

Neuroendocrine stress response will be measured by blood glucose level in adults undergoing umbilical hernia repair.

Time frame
24 hours postoperatively

Secondary outcomes

1

Serum cortisol level

Serum cortisol level will be measured.

Time frame
24 hours postoperatively
2

Time of first rescue analgesia

Time of first rescue analgesia will be recorded from the end of surgery till first dose of morphine administration.

Time frame
24 hours postoperatively
3

Total intraoperative fentanyl consumption

Rescue dose of intraoperative fentanyl given will be recorded.

Time frame
Intraoperatively
4

Total morphine consumption

Intravenous morphine (rescue analgesic) at a dosage of 3 mg will be administered when the Numerical Rating Scale (NRS) score will be ≥ 4. The total morphine consumption over a 24-hours period will be recorded for these individuals.

Time frame
24 hours postoperatively

Other outcomes

Sponsors and contacts

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