U-SCREEN is a randomized controlled trial evaluating whether systematic home-based multimodal screening for cardiovascular risk conditions, offered to residents in Region Uppsala turning 50, 55, 60, 65, 70 or 75 years of age, can identify clinically actionable cardiovascular risk factors more effectively than usual care. Participants randomized to the screening arm receive a home blood pressure measurement device, a dried blood spot sampling kit (for ApoB, HbA1c and creatinine), and a digital questionnaire. The control arm receives usual care. Recruitment runs 2024-2027 with a target identification of 10,000 cardiovascular risk conditions.
Resident in Region Uppsala, Sweden
Turning 50, 55, 60, 65, 70 or 75 years during recruitment period
Able to provide informed consent
Inability to provide informed consent
Protected identity
Parallel
Home-based multimodal cardiovascular screening
BehavioralSelf-administered home-based screening program: 7-day home BP, DBS biomarker self-sampling, digital questionnaire; structured digital return of results; threshold-based initiation of guideline-recommended pharmacotherapy and referral to clinical care.
Rate of total major adverse cardiovascular events over 10 years
Number of initiated guideline-recommended pharmacotherapies for cardiovascular risk factors within 12 months
All-cause mortality
Rate of cardiovascular deaths
Rate of total hospitalizations and deaths
Rate of cardiovascular hospitalizations and deaths from ischaemic heart disease
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