Health TrialsbyHealthPanel

Utility of PET-MRI in Surveillance of Paediatric Brain Tumours

ConditionBrain Tumor, Pediatric
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age8-18
SponsorSheffield Children's NHS Foundation Trust

About this trial

This is a pilot project to explore the utility of PET-MRI in the post-treatment surveillance of high-grade gliomas or medulloblastomas in children in our institution.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Have a presumptive or histologically confirmed diagnosis of a malignant brain tumour requiring treatment

Diagnostic uncertainty about tumour recurrence post-treatment based on conventional MR imaging in the opinion of the MDT

Have a life expectancy of at least three months

Able to comply with an MRI scan without a general anaesthetic

Disqualifiers

Unable to comply with an MRI scan without a general anaesthetic

Diabetes or other causes of hyperglycaemia

Pregnancy

Patient body habitus above scanner dimensions

Trial design

Design model

Single group

Treatments tested in this trial

  • PET-MRI

    Radiation

    magnetic resonance imaging with positron emission tomography scanning using the tracer 18F-FDG

Treatment groups

5 Participants
are divided into 1 treatment group
Group A: Diagnostic (PET-MRI)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Determine number of patients able to recruited for study in one year

Determine feasibility of recruitment for study by measuring the number of patients able to recruited for study in one year

Time frame
1 year

Secondary outcomes

1

Acceptability

Are the study design, procedures, and intervention appropriate from the perspective of the participants?

Time frame
1 year
2

Accuracy

determine the accuracy of FDG-PET vs MRI in determining residual tumour or tumour recurrence during post-treatment surveillance of high grade gliomas or medulloblastomas compared with biopsy results or clinical and radiological follow-up.

Time frame
1 year

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sheffield Children's NHS Foundation Trust

Lead sponsor

GE Healthcare

Collaborator

University of Sheffield

Collaborator

Source ClinicalTrials.gov
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