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Variation in the Impact of Coffee on the Metabolic Rate

ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorShenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

About this trial

The purpose of this study is to explore variation in the impact of coffee on metabolic rate. The investigators plan to recruit healthy participants, half male and half female.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Caffeine content

    Other intervention

    Participants will drink the same volume of coffee with different amounts of caffeine.

Treatment groups

100 Participants
are divided into 4 treatment groups
Group A: caffeine content 100mgExperimental treatment 1 intervention
Group B: caffeine content 200mgExperimental treatment 1 intervention
Group C: caffeine content 300mgExperimental treatment 1 intervention
Group D: 13C3 caffeine content 100mgExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Resting energy expenditure

Resting energy expenditure will be measured using indirect calorimetry via a respiratory hood system (COSMED). The subject attends in the lab after an overnight fast. The person lies down on a flat bed and the hood is placed over their head. Resting energy expenditure will be measured before and after coffee consumption. The extra energy expenditure is equal to the resting energy expenditure after drinking coffee minus the resting energy expenditure before drinking coffee.

Time frame
On the first moring of experiment, it lasts 0.5 hours and 3 hours.
2

Urine metabolites

The contents of metabolites will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).

Time frame
On the first moring of experiment, it lasts 0.5 hours and 3 hours.
3

Expired gases

Gases will be collected before and after coffee consumption, Gases will be measured by CO2 isotope analyzer (CCIA2-912) to observe the change of labelled CO2.

Time frame
On the first moring of experiment, it lasts 0.5 hours and 3 hours.

Secondary outcomes

1

Body temperature

Body temperature of participants will be measured by body temperature patch (RIT-P02-MED) before and after coffee consumption.

Time frame
On the first moring of experiment, it lasts 0.5 hours and 3 hours.
2

Electrocardiogram (ECG)

ECG of participants will be measured by Amu ECG belt before and after coffee consumption, the changes in P wave, PR interval, PR segment, QRS wave group, J point, ST segment, T wave, QT interval, and U wave will be observe.

Time frame
On the first moring of experiment, it lasts 0.5 hours and 3 hours.
3

Blood samples

Venous blood collected by nurses, blood samples will be used for whole genome exon sequencing to analyze single nucleotide polymorphisms.

Time frame
Baseline : empty stomach On the first moring of experiment.
4

Blood pressure

Systolic and diastolic blood pressure of participants will be measured by Omron digital sphygmomanometer before and after coffee consumption.

Time frame
On the first moring of experiment, it lasts 0.5 hours and 3 hours.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

Lead sponsor

Source ClinicalTrials.gov
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