Velocity-Based Resistance Training in Kidney Transplant Recipients
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorFundación Universitaria del Area Andina
About this trial
This randomized controlled trial aims to evaluate the effects of velocity-based resistance training on renal function and metabolic health in kidney transplant recipients. Participants will be randomized into two groups performing resistance training at different execution velocities (maximal intended vs. submaximal controlled). The intervention will last 12 weeks and include multi-joint exercises (squat, bench press, military press). Primary outcomes include renal function (serum creatinine, eGFR, blood urea nitrogen, uric acid) and metabolic markers (HDL, triglycerides, glucose, waist circumference, blood pressure). Secondary outcomes include muscle strength, force-velocity profile, anthropometry, physical activity, fitness perception, and adherence to immunosuppressive medication.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Men and women aged 18 to 50 years.
Kidney transplant performed ≥12 months before enrollment.
Stable graft function in the previous 6 months (serum creatinine < 1.5 mg/dL, no rejection episodes).
Written medical clearance from a nephrologist to perform moderate-to-vigorous physical activity.
Disqualifiers
Active autoimmune disorders.
Recent coronary disease (≤6 months).
Severe musculoskeletal limitations incompatible with resistance training.
Diagnosis of diabetes mellitus (pre- or post-transplant).
Trial design
Design model
Parallel
Treatments tested in this trial
Velocity-Based Resistance Training - Submaximal Velocity Protocol
Other interventionA 12-week supervised resistance training program performed 3 sessions per week. Exercises will include bench press, squat, and shoulder press in Smith machine. Participants will execute each repetition at \~50% of maximal concentric velocity, with sets completed according to predetermined repetitions (20-30 depending on load, 20-60% 1RM).
Velocity-Based Resistance Training - Maximal Velocity Protocol
Other interventionA 12-week supervised resistance training program performed 3 sessions per week. Exercises will include bench press, squat, and shoulder press in Smith machine. Participants will execute each repetition at maximal concentric velocity, with sets terminated at 20% velocity loss. Training loads will increase progressively (20-60% 1RM).
Treatment groups
12 Participants
are divided into 2 treatment groupsGroup A: Experimental - Maximal Velocity GroupExperimental treatment 1 intervention
Group B: Submaximal Velocity GroupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Serum creatinine (mg/dL) - change from baseline
Serum creatinine will be measured from venous blood samples processed in an external certified laboratory (IDIME, Bogotá). This parameter will serve as a biomarker of renal graft function.
Time frame
Baseline and week 13 (after completion of 12-week intervention)2
Estimated glomerular filtration rate (eGFR, mL/min/1.73 m²) - change from baseline
The estimated glomerular filtration rate (eGFR) will be calculated from serum creatinine using validated equations (CKD-EPI or MDRD). This measure will serve as the most sensitive indicator of renal graft function.
Time frame
Baseline and week 13 (after completion of 12-week intervention)3
Blood urea nitrogen (BUN, mg/dL) - change from baseline
Blood urea nitrogen will be measured to monitor renal clearance capacity and metabolic status.
Time frame
Baseline and week 13 (after completion of 12-week intervention)4
Serum Uric Acid (mg/dL)
Serum uric acid will be measured as a biomarker of renal excretory capacity and cardiovascular risk.
Time frame
Baseline and week 13 (after completion of 12-week intervention)Secondary outcomes
1
Handgrip strength
Handgrip strength will be assessed using a digital dynamometer (Takei Scientific Instruments, Tokyo). Two trials per hand, best value recorded. This test reflects overall muscle strength.
Time frame
Baseline and week 13 (after completion of 12-week intervention)2
Body Composition (fat percent, muscle percent, visceral fat)
Body composition will be assessed using segmental bioelectrical impedance analysis (Tanita IRONMAN BC-1500). Measurements will include fat percentage, muscle percentage, and visceral fat.
Time frame
Baseline and week 13 (after completion of 12-week intervention)3
Force-Velocity Profile
:The force-velocity profile will be assessed using a linear encoder (T-Force) during three multi-joint exercises (bench press, squat, overhead press). The relationship between force and velocity will be calculated to estimate neuromuscular performance.
Time frame
Baseline and week 13 (after completion of 12-week intervention)4
Body Height (cm)
Body height will be measured with a digital stadiometer following the Frankfurt plane reference to ensure standardized posture.
Time frame
Baseline and week 13 (after completion of 12-week intervention)Sponsors and contacts
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Source ClinicalTrials.gov