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Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases

ConditionGuillain-Barre Syndrome
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-55
SponsorCairo University

About this trial

The aim of the current study is to compare the effect of ventilator trigger sensitivity adjustment versus threshold inspiratory muscle training on arterial blood gases in mechanically ventilated patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Difficult to wean Guillain barre patients who have been on MV for at least 48 hours. Difficult to wean subjects have been defined as those who fail the first spontaneous breathing trial (SBT)and may require up to 3 SBTs or up to 7 d from the first attempt to achieve successful weaning (B´eduneau G. et al.,2017) and (Annia F. et al.,2019).

Age: >18 years.

Both sexes will be included.

Ventilator mode: Pressure support mode with FiO2≤ 0.5, positive end expiratory pressure (PEEP) will be<8-10cm/H2Oand respiratory rate < 25.

Disqualifiers

Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure.

Severe breathlessness, when spontaneously breathing.

Any progressive neuromuscular disease that would interfere with responding to inspiratory muscle training (non-stationary course).

Spinal cord injury.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Threshold inspiratory muscle trainer or ventilator pressure setting inspiratory muscle training techniques

    Other intervention

    New techniques to train inspiratory muscles in mechanically ventilated patients

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: Threshold inspiratory muscle trainerExperimental treatment 1 intervention
Group B: Ventilator pressure setting inspiratory muscle trainingExperimental treatment 1 intervention
Group C: Traditional treatmentNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

PH

To measure PH

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks
2

PaO2

To measure partial pressure of oxygen

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks
3

PaCO2

To measure partial pressure of carbon dioxide

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks
4

HCO3

To measure bicarbonate

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks

Secondary outcomes

1

Rapid shallow breathing index

To measure respiratory endurance

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks
2

The Horowitz index

To measure PaO2 /FiO2 ratio

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks
3

Glasgow coma scale

To measure level of consciousness

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks
4

Riker Sedation-Agitation Scale

Arousal/sedation assessment

Time frame
Pre intervention and immediate post intervention, through study completion, an average of two weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov
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