Ventilatory Parameters in Predicting Outcomes in ARDS Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age19-80
SponsorCentraCare
About this trial
This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with Acute respiratory failure needing mechanical ventilation
Diagnosis of Severe ARDS with severity: PF ratio < 150, with PEEP/CPAP > 5
Disqualifiers
r2 < 0.95, monitored on the ventilator
Expiratory flow that is not first-order or non-exponential decay
Patients with Nor-epinephrine requirements > 0.1 mcg/kg/min within 2 hours of intubation
Patients requiring ECMO ( Extracorporeal membrane oxygenation)
Trial population
For those patients, who satisfy inclusion and exclusion criteria, Day 1 will be considered as the the day of intubation. Age , gender, Charleston co-morbidity index , SOFA score at the time of intubation. For day 1 to day 3, we shall record average values of Pocc, TCe, C20/C index, Ventilatory ratio, Mechanical stress power , PF ratio will be recorded. Outcome data such as need for vasopressors, prone position, duration of ICU stay, MAKE outcomes, need for paralysis, change in mode of ventilator, ventilator number of days, hospital stay and 30 days outcomes including disability and survival.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Poccl, Time constant, driving pressure
Diagnostic testVentilatory parameters
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Survival or mortality
We will assess whether the patient would survive or not
Time frame
From the date of enrollment to 90 days from enrolment or date of death, whichever came first, assessed up to 90 days.Secondary outcomes
1
MAKE ( Major adverse kidney events)
Will assess the need for dialysis or any evidence of acute kidney injury
Time frame
From the date of enrollment to 90 days from enrolment or date of death, whichever came first, assessed up to 90 days.2
ICU and Hospital length of stay
we shall assess the duration of patients stay in the ICU and in the hospital
Time frame
From the date of enrollment to the number of days in ICU and in the hospital until discharge or date of death whichever came first, assessed up to 90 days Source ClinicalTrials.gov