Aggression

22

Review clinical trials related to Aggression. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Momentary Coping Prompts and Hair Steroids in College Students

This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions. Participants wear a wrist device and answer brief check-ins on their phone several times a day for about five weeks. During part of that time, a study app sometimes sends a short coping message at moments when the wrist device and check-ins suggest emotions are shifting quickly. Whether a message is sent at any given moment is decided at random, and the study compares what participants do in the short window afterward. An optional part of the study collects one small hair sample, which is tested for two hormones related to stress and to status-linked behavior, so the researchers can see whether longer-term hormone levels relate to how people respond in the moment. The study is a pilot designed to test whether the approach works and to estimate how large its effects are.

Participants needed: 80
Trial details
Age: 18-89Biological sex: AllType: InterventionalSponsor: University of FloridaUpdated: Oct 1, 2026Locations: 1
Eligibility criteria

Currently enrolled University of Florida student [+4]

Varsity student-athlete governed by the university athletic association [+1]

Status: Recruiting

Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism

The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors. Participants will be randomly assigned to receive either propranolol or a placebo (a look-alike substance that contains no drug) daily for 12 weeks. After the 12 weeks, all participants will have the opportunity to receive propranolol for an additional 12 weeks.

Participants needed: 60
Trial details
Phase: Phase 2Age: 12-40Biological sex: AllType: InterventionalSponsor: Jeremy Veenstra-vanderweeleUpdated: Sep 1, 2026Locations: 2
Eligibility criteria

Age between 12-40 years. [+10]

Those who are unable to provide informed consent and have no parent/guardian/leg... [+17]

Status: Recruiting

Addressing Root Causes for Gun Violence Prevention (ARC-GVP)

The goal of this study is to help build the evidence base for a locally-relevant youth firearm violence prevention program in Washington D.C., a city experiencing disparities in youth firearm violence outcomes. The main question it aims to answer is: How is youth participation in the summer youth employment program, the True Reasons I Grabbed the Gun Evolved from Risk (The T.R.I.G.G.E.R Project), which is designed to address root causes of gun violence, associated with individual youth behavioral outcomes, including pro-social involvement, aggression, and firearm-related attitudes and behaviors?

Participants needed: 250
Trial details
Age: 14-24Biological sex: AllType: ObservationalSponsor: University of MichiganUpdated: Aug 31, 2026Locations: 1
Eligibility criteria

Youth in Washington D.C. who are participating in The T.R.I.G.G.E.R Project, a g...

Emancipated minors

Status: Not yet recruiting

Just-in-Time Coping Prompts for Reactive Digital Behavior in College Students

This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions. Participants wear a wrist device and answer brief check-ins on their phone several times a day for about five weeks. During part of that time, a study app sometimes sends a short coping message at moments when the wrist device and check-ins suggest emotions are shifting quickly. Whether a message is sent at any given moment is decided at random, and the study compares what participants do in the short window afterward. The study is a pilot designed to test whether the approach is feasible and to estimate how large its effects are.

Participants needed: 80
Trial details
Age: 18-89Biological sex: AllType: InterventionalSponsor: University of FloridaUpdated: Aug 27, 2026Locations: 1
Eligibility criteria

Currently enrolled University of Florida student [+3]

Varsity student-athlete governed by the university athletic association [+1]

Status: Not yet recruiting

Effect of Verbal De-Escalation-Based Simulation on Agitation Management, Perception of Aggression, and Impact of Aggression in Emergency Department Nurses

This mixed-methods randomized controlled study aims to evaluate the effects of verbal de-escalation-based simulation training on emergency department nurses' knowledge of agitation management, perceptions of aggression, and the extent to which they are affected by aggressive and violent behaviors. A total of 78 emergency department nurses will be randomly assigned to an intervention group (n=39) or a control group (n=39). Both groups will receive the same standard training program on verbal de-escalation-based agitation management. After the standard training, the intervention group will participate in standardized patient simulation and debriefing sessions. Outcomes will be assessed before the intervention, after the intervention, and at a three-month follow-up. In addition, focus group interviews will be conducted with participants in the intervention group at the three-month follow-up to explore their experiences with the simulation-based training.

Participants needed: 78
Trial details
Biological sex: AllType: InterventionalSponsor: Uskudar UniversityUpdated: Aug 25, 2026Locations: 1
Eligibility criteria

Working as a nurse in the adult emergency department of the hospital where the s... [+2]

Being on leave or otherwise unable to work during the study period [+1]

Status: Recruiting

The Use of Transcranial Direct Current Stimulation (tDCS) in Adults With Developmental Disabilities

Aggressive behaviours are highly prevalent among people with developmental disabilities, both in community and inpatient or residential settings, with adverse consequences for the individuals involved and others. Some predictive factors, particularly impulsivity, are dynamic with neurobiological underpinnings, and as such amenable to change or neuromodulation using non-invasive brain stimulation techniques. With this in mind, we designed an experimental protocol to determine the efficacy of transcranial Direct Current Stimulation (tDCS) as a non-invasive brain stimulation technique to reduce impulsivity and aggression associated with developmental disability.

Participants needed: 60
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Dr. Najat KhalifaUpdated: Aug 12, 2026Locations: 1
Eligibility criteria

Adults aged 18-64 years [+3]

History of epilepsy or seizures [+9]

Status: Recruiting

Refinements of Functional Communication Training

Although treatments for problem behavior, like functional communication training (FCT), can be highly effective in the clinic, changes in the way the FCT is implemented (e.g., when transferring treatment to the home, when teachers implement treatment with poor fidelity) can result in treatment relapse. The goal of this study is to evaluate whether using treatment signals and gradually introducing materials from natural contexts can help mitigate treatment relapse during context changes and poor treatment-integrity scenarios.

Participants needed: 24
Trial details
Age: 3-17Biological sex: AllType: InterventionalSponsor: Rutgers, The State University of New JerseyUpdated: Jun 17, 2026Locations: 1
Eligibility criteria

Boys and girls from ages 3 to 17 [+4]

Patients who do not meet the inclusion criteria [+5]

Status: Recruiting

A Virtual Reality Mindfulness Application for Aggression in Schizophrenia

The study investigates whether a virtual reality-based mindfulness based intervention can reduce impulsive aggression in individuals with schizophrenia or schizoaffective disorder. The primary goal is to evaluate whether mindfulness delivered via VR (MBI-VR) improves emotion regulation and engages the dorsomedial prefrontal cortex (dmPFC), a brain region involved in cognitive control and regulation of emotional responses. The study also examines whether these effects show a dose-related relationship. Participants will be randomized to receive different doses of MBI-VR intervention or distraction tasks and will complete repeated mindfulness VR sessions. Brain activity will be measured using functional magnetic resonance imaging (fMRI) during an emotion regulation task, along with clinical assessments of impulsive aggression related symptoms.

Participants needed: 58
Trial details
Age: 18-64Biological sex: AllType: InterventionalSponsor: Manhattan Psychiatric CenterUpdated: Jun 10, 2026Locations: 2
Eligibility criteria

Is willing and able to provide written informed consent to participate in the st... [+7]

Have past head trauma [+8]

Status: Not yet recruiting

Intensive Care Unit Conflict Mediation Study

To evaluate the impact of a structured, multidisciplinary conflict management program incorporating an interprofessional Singular Care Plan \*PAS\* Committee and a Conflict Mediation Team on the incidence and severity of conflicts, family satisfaction, and staff well-being in an adult intensive care unit \*ICU\*

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hospital Israelita Albert EinsteinUpdated: Jun 2, 2026
Eligibility criteria

Not listed

Status: Not yet recruiting

Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji

Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt. Sunlight-reflecting cool roof coatings may passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions in Fiji are susceptible to increased heat exposure. Heat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are experienced in communities that are least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in household occupants. The long-term research goal of the investigators is to identify viable passive housing adaptation technologies with proven health benefits to reduce the burden of heat stress in communities affected by heat in Fiji. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in Tavua, Fiji.

Participants needed: 800
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Aditi BunkerUpdated: May 18, 2026Locations: 1
Eligibility criteria

Permanent household resident.

Roof damage, inaccessible or instability of roof adversely affecting cool roof c... [+1]

Status: Recruiting

Manualized Assessment and Treatment Model of Challenging Behavior

Despite decades of mounting single-case-design evidence for the efficacy of applied behavior analysis (ABA) and other approaches for the assessment and treatment of challenging behavior, an evidence-based comprehensive approach remains to exist. The current study will collect test the efficacy of a standardized manual for assessing and treating challenging behavior for individuals with severe and mild challenging behavior.

Participants needed: 30
Trial details
Age: 3-17Biological sex: AllType: InterventionalSponsor: Rutgers, The State University of New JerseyUpdated: May 8, 2026Locations: 1
Eligibility criteria

children from ages 3 to 17; [+5]

patients who do not meet the inclusion criteria; [+5]

Status: Recruiting

Basic and Applied Research on Extinction Bursts

Although highly effective, treatments like FCT include extinction, which can have adverse side effects. The extinction burst, an increase in the frequency or intensity of destructive behavior at the start of treatment, is the most common side effect of extinction, and can increase the risk of harm to the patient and others. The goal of the current study is to evaluate the prevalence of extinction bursts when various parameters of reinforcement (i.e., rate, magnitude, quality) are manipulated.

Participants needed: 40
Trial details
Age: 3-17Biological sex: AllType: InterventionalSponsor: Rutgers, The State University of New JerseyUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

children aged 3 to 17; [+5]

patients currently receiving 15 or more hours per week of treatment for their pr... [+4]

Status: Recruiting

Extensions of Resurgence as Choice

Although behavioral treatments for decreasing destructive behavior, such as differential reinforcement of alternative behavior (DRA), are effective in the clinic, problem behavior often returns when a caregiver does not give the child their way in the natural environment (e.g., caregiver is busy with an infant sibling). This form of treatment relapse is known as resurgence. The goal of the current study is to evaluate whether alternating sessions in which the child can have their way (i.e., "on" sessions) with sessions in which the child can not have their way (i.e., "off" sessions) helps to mitigate resurgence.

Participants needed: 30
Trial details
Age: 3-17Biological sex: AllType: InterventionalSponsor: Rutgers, The State University of New JerseyUpdated: Apr 17, 2026Locations: 1
Eligibility criteria

boys and girls from ages 3 to 17; [+5]

patients who do not meet the inclusion criteria; [+5]

Status: Not yet recruiting

Creative Drama on Gender Role Stress, Attitudes Toward Violence Against Women, and Aggression

This study aims to examine the effect of Creative Drama on gender role stress, attitudes toward violence against women, and aggression among men who experienced the February 6, 2023 earthquake in Türkiye (centered in Kahramanmaraş). A total of 75 men (25 experimental, 25 placebo, and 25 control) will participate in the study. The experimental group will take part in a creative drama program, the placebo group will watch films focusing on masculinity roles and violence for 10 weeks, and no intervention will be applied to the control group. Data will be collected using the Gender Role Stress Scale for Men, the Attitudes Toward Violence Against Women Scale, and the Buss-Perry Aggression Questionnaire - Short Form, and will be analyzed by an independent statistician. The study aims to enhance the psychological well-being of men affected by the earthquake in Türkiye, reduce violence against women, and contribute to gender equality.

Participants needed: 75
Trial details
Age: 18-65Biological sex: MaleType: InterventionalSponsor: Ataturk UniversityUpdated: Apr 9, 2026
Eligibility criteria

Not listed

Status: Recruiting

Treatment of Chronic Anger and Aggression Following Military-Related Betrayal

The goal of this clinical trial is to learn if a treatment designed to deal with anger and aggression from a past betrayal will work. The study will be done on active duty military service members and veterans aged 18 or older. The main questions it aims to answer are: * Will participants be satisfied with the treatment, and is the treatment feasible to do in a military outpatient setting * Will the treatment help with anger and aggression issues. Researchers will compare differences in groups that have different wait times (2-, 3-, or 4-weeks). Participants will complete surveys before, during and after the treatment. The treatment will be 14 modules given twice a week. About 1 month after treatment ends, surveys will be taken again.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: The University of Texas Health Science Center at San AntonioUpdated: Apr 1, 2026Locations: 1
Eligibility criteria

Adult active duty military service members and veterans aged 18 or older. [+3]

Participated in an anger management or trauma-focused intervention within the pa... [+5]

Status: Recruiting

Virtual Reality Intervention (VR-GINSO) for Reducing Aggression in Young Offenders

The goal of this clinical trial is to see if a specific intervention program that uses virtual reality (VR) helps young people reduce aggressive behavior more than the same program without VR or their usual treatment. The study will also look at how the program affects anger, impulsivity, emotional control, and how participants understand and handle conflicts with others. The main questions the study wants to answer are: * Does the intervention program with VR help young people reduce aggressive behavior more than the same program without VR or just their usual treatment? * What changes in the mind and body are linked to improvements in aggressive behavior and emotional control? The researchers will compare three groups of young people: * Usual treatment plus the 4-session intervention program with VR. * Usual treatment plus the 4-session intervention program without VR. * Usual treatment only. Participants will: * Attend 4 individual sessions lasting 1 to 1.5 hours, once a week. * Take part in activities to learn how to recognize emotions, understand conflict situations, and manage anger and impulsivity. * Complete questionnaires about aggressive behavior, anger, impulsivity, emotional control, and how they interpret conflicts. * Have their aggressive behavior recorded through disciplinary reports at the center. * Provide saliva samples before and after sessions to measure hormones related to stress and aggression. * Wear a chest band that measures heart rate and a headset that records brain activity during the VR activities. All data will be kept confidential, and the identities of participants will be protected at all times.

Participants needed: 110
Trial details
Age: 12-18Biological sex: AllType: InterventionalSponsor: Universidad Francisco de VitoriaUpdated: Mar 20, 2026Locations: 1
Eligibility criteria

12-18 years old at the moment of recruitment and allocation. [+2]

Neurological disorder, brain injury, or psyquiatric pathology that affects cogni... [+1]

Status: Not yet recruiting

Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico

Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change. Sunlight-reflecting cool roof coatings may passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions in the northern zone of Mexico are susceptible to increased heat exposure. Heat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are experienced in communities that are least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in household occupants. The long-term research goal of the investigators is to identify viable passive housing adaptation technologies with proven health benefits to reduce the burden of heat stress in communities affected by heat in Mexico. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in Colima, Mexico.

Participants needed: 800
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Aditi BunkerUpdated: Mar 12, 2026Locations: 1
Eligibility criteria

Permanent household resident.

Roof damage, inaccessible or instability of roof adversely affecting cool roof c... [+1]

Status: Recruiting

Step-by-Step: Evaluation of a Stepped Care Model

The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children's defiant or aggressive behavior problems. The stepped model consists of a brief internet-based parenting support program (Step 1). For those with continued need of additional interventions, Step 2 includes access to one of following interventions: b) a Cognitive Behavior Therapy (CBT) -Virtual Reality (VR)-assisted parenting support program, b) a Cognitive Behavior Therapy -Virtual Reality-assisted child intervention, or c) standard interventions/support at the family's unit/clinic and continued access to the study's internet-based parenting support program, after which the family may choose CBT-VR for the child or the parent.

Participants needed: 210
Trial details
Age: 8-16Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Mar 6, 2026Locations: 1
Eligibility criteria

Families with children aged 8-16 years who have difficulty controlling anger or... [+2]

Families with children younger than 8 years old or who have already turned 17, o... [+3]

Status: Recruiting

Assessing the Effects of Cool Roofs on Indoor Environments and Health

Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities. Sunlight-reflecting cool roof coatings passively reduce indoor temperatures and energy use to protect home occupants from extreme heat. Occupants living in poor housing conditions globally - for example in informal settlements, slums, and low-socioeconomic households - are especially vulnerable to increased indoor heat exposure. Heat exposure can instigate and worsen numerous physical, mental and social health conditions. The worst adverse health effects are being experienced in communities least able to adapt to heat exposure. By reducing indoor temperatures, cool roof use can promote physical, mental and social wellbeing in occupants. The long-term research goal is to identify viable passive housing adaptation technologies with proven health and environmental benefits to reduce the burden of heat stress in communities affected by heat globally. To meet this goal, the investigators will conduct a cluster-randomized controlled trial to establish the effects of cool roof use on health, indoor environment and economic outcomes in five urban climate hotspots: Ouagadougou, Burkina Faso; Colima, Mexico; Ahmedabad, India; Niue; and Tavua, Fiji.

Participants needed: 3,200
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Aditi BunkerUpdated: Feb 27, 2026Locations: 5
Eligibility criteria

Permanent household resident.

Roof damage, inaccessible or instability of roof adversely affecting cool roof c... [+1]

Status: Not yet recruiting

Managing Aggression: Effectiveness of Model-Based Standardized Patient Simulation

This study aims to evaluate the effectiveness of standardized patient simulation based on "The De-Escalation Model in Simple Form" on nursing students' perceptions of aggression and perceived learning outcomes. Encountering aggressive and violent patient behavior is a common and challenging experience for nursing students. Simulation-based education offers experiential learning opportunities that can enhance students' confidence and clinical decision-making skills. The study was designed using a convergent parallel mixed-methods approach. The quantitative component consists of a randomized controlled trial design in which participants will be randomly assigned to either the intervention group or the control group. Primary and secondary outcome measures related to aggression perception and perceived learning will be assessed post-test in both groups. The intervention group will receive training based on the De-Escalation Model in Simple Form, followed by participation in an aggression management simulation with a standard patient. After the simulation, qualitative data will be collected from participants in the intervention group to examine their experiences, perceptions, and reactions to the intervention and simulation process. Quantitative and qualitative findings will be analyzed to provide a comprehensive understanding of the intervention's effectiveness and implementation process. The results of this study are expected to contribute to evidence-based educational practices aimed at improving nursing students' skills in managing aggressive patient behavior.

Participants needed: 56
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yuksek Ihtisas UniversityUpdated: Feb 27, 2026Locations: 1
Eligibility criteria

being 18 years of age [+2]

refusing to participate in the study

Status: Recruiting

Cognitive Remediation in Forensic Mental Health Care

Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation. One empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching. This trial investigates whether cognitive remediation can improve cognitive, functional, and clinical outcomes in forensic inpatients.

Participants needed: 30
Trial details
Age: 18-55Biological sex: AllType: InterventionalSponsor: The Royal Ottawa Mental Health CentreUpdated: Dec 12, 2025Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

Motivational Interviewing-Based Training

The middle school period is the period when children begin to experience physical, emotional and social development and try to adapt to psychological changes. In this age group, which is seen as a transition period, the child's academic success and acceptance by peers and friends are also important. The problems experienced during this period can continue in adulthood and children are more likely to experience loneliness, sleep disorders, depression, anxiety, eating disorders, low self-esteem, suicidal thoughts, absenteeism and a decrease in academic success. For this reason, early detection of risky behaviors that threaten children's health and evaluation of health promotion practices are very important issues for child health nursing. In recent years, peer bullying, aggression and social exclusion have increased and continue to increase in the middle school period, also called early adolescence. For this purpose, a study was needed to identify the situation in middle school students and reduce this negativity. In this respect, it is thought that the study will contribute to the literature. In addition, if the hypotheses of the study are confirmed, it is expected that similar training will be provided in other schools and contribute to the reduction of risky behaviors. The aim of this study is to determine the effects of motivational interviewing-based education on peer bullying, social exclusion and aggression in secondary school students and to offer suggestions for situations where deficiencies are observed based on the findings obtained.

Participants needed: 80
Trial details
Age: 12-13Biological sex: AllType: InterventionalSponsor: Muş Alparslan UniversityUpdated: May 21, 2025Locations: 1
Eligibility criteria

Being 12-13 years old [+5]

Having a low score on the ''Peer Bullying Determination Scale'' [+3]