Enamel Hypomineralization

2

Review clinical trials related to Enamel Hypomineralization. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Clinical Performance of Orthodontic Bands in the Restorative Treatment of Hypomineralised Primary Second Molars

This randomised clinical trial will compare the clinical performance and acceptability of orthodontic bands and preformed stainless steel crowns for the restorative management of hypomineralised second primary molars. Thirty children aged 5-10 years will be randomly allocated in a 1:1 ratio to receive either an orthodontic band or a stainless steel crown. One index tooth per participant will be evaluated immediately after treatment and at 6, 12, and 18 months. The primary outcomes will be marginal adaptation, retention, and the presence of carious lesions. Secondary outcomes will include biofilm accumulation and treatment acceptability among children and their caregivers.

Participants needed: 30
Trial details
Age: 5-10Biological sex: AllType: InterventionalSponsor: Universidade Federal do Rio Grande do NorteUpdated: Sep 15, 2026Locations: 1
Eligibility criteria

Children aged 5-10 years. [+2]

Extensive carious lesion with subgingival margins. [+4]

Status: Recruiting

Hydroxyapatite Toothpastes and Enamel Remineralization:

This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions. The study compares Biorepair® Total Protection Plus, which contains biomimetic microRepair particles, with Bioniq® Repair, a conventional hydroxyapatite-based toothpaste. Forty participants will be randomly assigned to either the trial group (Biorepair®) or the control group (Bioniq®), and both groups will receive quarterly professional dental cleanings and use the assigned toothpaste twice daily for 6 months. The primary outcome is the change in enamel demineralization, assessed by DIAGNOdent Pen scores, in permanent molar fissures and upper central incisors. Secondary outcomes include enamel integrity assessed by DIAGNOcam imaging and ICDAS scores, as well as changes in dental sensitivity (Schiff Air Index), erosive wear (BEWE Index), plaque accumulation (Plaque Index), gingival inflammation (Bleeding Index), and extrinsic stains (Modified Lobene Stain Index). Patient satisfaction will also be evaluated at the end of the study using a self-administered questionnaire. This study will help determine whether biomimetic hydroxyapatite offers superior benefits in maintaining enamel health compared to conventional formulations, supporting evidence-based preventive strategies in dental care.

Participants needed: 40
Trial details
Age: 6-18Biological sex: AllType: InterventionalSponsor: University of PaviaUpdated: Feb 20, 2026Locations: 1
Eligibility criteria

Subjects aged between 6 and 18 years [+5]

DIAGNOdent Pen values greater than 25 [+4]