Failed Back Surgery Syndrome (FBSS)

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Review clinical trials related to Failed Back Surgery Syndrome (FBSS). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)

This study aims to analyze the efficacy and safety of different kinds of steroid injections for back pain, comparing different steroids, dosages, locations (epidural, facet joints, nerve blocks), and also the difference between injections with steroids and local anesthetics, to optimize this treatment that is currently not standardized. The investigators will compare retrospectively and prospectively the efficacy of different injections in the same patients, using mainly a parameter called integral of pain relief, which combines the percentage of pain relief provided by a treatment and its duration over time, as well as improvements in functionality.

Participants needed: 500
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: Igor Wilderman. MDUpdated: Aug 13, 2026Locations: 1
Eligibility criteria

>18 years of age; [+4]

Diagnosis of dementia, Parkinson's disease or other cognitive impairments; [+4]

Status: Not yet recruiting

Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery

Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects. This randomized, sham-controlled trial aims to compare the efficacy of CFT versus a sham intervention (detuned photobiomodulation) in participants with chronic low back pain after spinal surgery.

Participants needed: 90
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Centro Universitário Augusto MottaUpdated: May 8, 2026
Eligibility criteria

Age 18-75 years [+4]

Serious spinal pathology [+4]

Status: Recruiting

Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)

This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS). Patients with Persistent Spinal Pain Syndrome Type 2 (FBSS/FNSS) will undergo a standard 21-day SCS trial with the Evoke closed-loop system, followed by permanent implantation if successful. Neurophysiological responses (activation plots, conduction velocity, chronaxie, rheobase) and patient-reported outcomes (VAS, activity, sleep, medication intake) will be collected during the trial and up to 6 months after implantation. The goal is to evaluate the relationship between medication tapering and spinal cord sensitivity

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Brai²nUpdated: Mar 31, 2026Locations: 1Duration: 6 Months
Eligibility criteria

Candidate for SCS and scheduled for trial with Evoke system. [+9]

Active disruptive psychiatric disorder or condition impacting pain perception or... [+5]