Gum Disease

5

Review clinical trials related to Gum Disease. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

CHEER Oral Health in Pregnancy Study

Many pregnant people don't get the dental care they need, even though it's safe and important. The CHEER Study offers free dental check-ups, cleanings, and supplies to help participants take care of their teeth and gums during pregnancy. The purpose of this research study is to compare two types of noninvasive oral health interventions to evaluate their effectiveness. We want to learn if one method is more effective in supporting oral health and improving pregnancy outcomes. There are two aims of this study: Aim 1: To evaluate whether a structured oral health intervention reduces periodontal inflammation during pregnancy and postpartum in pregnant people with indicators of periodontal disease. Aim 2: To assess whether a structured oral health intervention is associated with changes in oral health behaviors or birth outcomes in pregnant people with periodontal disease.

Participants needed: 160
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: University of California, San FranciscoUpdated: Oct 8, 2026Locations: 1
Eligibility criteria

Pregnant individuals aged 18 years or older with indications of periodontal dise... [+5]

Presence of systemic diseases or medical conditions that require antibiotic prop... [+6]

Status: Not yet recruiting

Womens Health Screening and the Oral Microbiome

The overall aims of this project are to undertake a women's health screening clinic on oral health and systemic health, linking the oral microbiome to hormonal status (menopause); The follow quantitative and qualitative markers of oral health will be used: * Salivary and systemic female hormone status * Systemic/cardiovascular health markers, such as blood pressure, cholesterol and blood glucose * Clinical oral health variables (markers of plaque and gum disease) * Physiological and biochemical markers, such as salivary nitrate and nitrite * Oral microbiome * Breath analysis (volatile sulphur comounds) * Perceptions of mouth discomfort

Participants needed: 240
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: University of PlymouthUpdated: Oct 6, 2026Locations: 1
Eligibility criteria

We will recruit female participants who are current Peninsula Dental School pati...

As this study focuses on the oral microbiome, salivary biomarkers alongside peri...

Status: Not yet recruiting

Effectiveness of Personalized Oral Hygiene Advice Delivered by Artificial Intelligence or Dental Professionals Versus Standard Oral Hygiene Advice on Oral and Systemic Health in Community-based Type II Diabetes Patients

Diabetes is a systemic condition characterized by elevated blood glucose levels and is associated with multiple long-term complications. This systemic disease is mutually linked to inflammatory gum diseases through circulating inflammatory mediators. Controlling inflammatory gum diseases by maintaining oral hygiene improves blood glucose levels and reduces long-term complications. However, close supervision of good oral hygiene through home care is labor-intensive and expensive. Artificial Intelligence (AI) has been used to provide personalized advice on the adequacy of patients' home care (oral hygiene). The investigators hypothesize that the use of AI can improve home care, thereby enhancing both gum health and systemic health, similar to human dental professionals and standardised oral health instructions.

Participants needed: 105
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: The University of Hong KongUpdated: Oct 1, 2026
Eligibility criteria

Subjects who are >18 years of age and able to give informed consent. [+4]

Subjects who have mental illness, or similar problems that unable to complete th... [+1]

Status: Recruiting

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

The purpose of this clinical study is to determine the effectiveness of the Erchonia® FX-405 (manufactured by Erchonia Corporation (the Company) in providing a noninvasive adjunctive treatment in combination with periodontal scaling and root planing for improving the treatment of periodontal disease.

Participants needed: 70
Trial details
Age: 22-75Biological sex: AllType: InterventionalSponsor: Erchonia CorporationUpdated: May 18, 2026Locations: 2
Eligibility criteria

Subject has voluntarily signed a written informed consent form. [+8]

Gingival recession which may be genetic, induced secondary to orthodontic treatm... [+4]

Status: Recruiting

Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by AI

Prediabetes is an intermediate stage before the development of diabetes, characterized by elevated blood glucose levels but lower than the diagnostic criteria of diabetes and is associated with multiple long-term complications. This systemic disease is mutually linked to inflammatory gum diseases through circulating inflammatory mediators. Controlling inflammatory gum diseases improves blood glucose levels and reduces long-term complications. While maintaining good oral hygiene through home care is essential for managing inflammatory gum diseases, close supervision of patients' home care is labor-intensive and expensive. Artificial Intelligence (AI) has been used to provide personalized advice on the adequacy of patients' home care (oral hygiene). The investigators hypothesize that the use of AI can improve home care, thereby enhancing both gum health and systemic health, similar to human dental professionals.

Participants needed: 148
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: The University of Hong KongUpdated: Dec 3, 2025Locations: 1
Eligibility criteria

- Subjects who are >18 years of age and able to give informed consent. [+5]

- Subjects who have less than 6 anterior maxillary or mandibular natural teeth w... [+3]