Hemorrhoids Third Degree

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Review clinical trials related to Hemorrhoids Third Degree. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Comparing Rectal Artery Embolization and Surgery for Treatment of Bleeding Grade 2 and 3 Internal Hemorrhoids

This Phase II study will compare rectal artery embolization with operative hemorrhoidectomy in adults with symptomatic bleeding grade 2 and 3 internal hemorrhoids. Participants will be randomly assigned to receive one of the two treatments. The study will evaluate how each treatment affects quality of life, symptom improvement, bleeding control, recovery time, and treatment-related side effects. The main question this study is trying to answer is whether rectal artery embolization can provide better short-term quality of life compared with surgical hemorrhoidectomy one month after treatment. The study will also examine whether rectal artery embolization allows patients to return to work and normal activities sooner, reduces hemorrhoid-related bleeding, and has a different rate of treatment-related complications compared with surgery. A total of approximately 102 adult participants will be enrolled at a single academic medical center. The results of this study may help determine whether rectal artery embolization is an effective and less invasive alternative to surgical hemorrhoidectomy for the treatment of bleeding grade 2 and 3 internal hemorrhoids.

Participants needed: 102
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: University of Colorado, DenverUpdated: Sep 28, 2026Locations: 1
Eligibility criteria

Male or female, aged >18 years [+9]

Current use of anticoagulants and/or DAPT [+15]

Status: Recruiting

HELO Trial: Energy-Based Therapies vs. Conventional Hemorrhoidectomy for Grade III Hemorrhoids

This prospective, multicenter study compares the efficacy and functional outcomes of three surgical treatments for symptomatic Goligher Grade III internal hemorrhoids: Laser Hemorrhoidoplasty (LHP), Hemorrhoid Energy Therapy (HET), and conventional closed hemorrhoidectomy (Ferguson technique). Due to strong patient preferences in hemorrhoidal surgery, this study utilizes a pragmatic, preference-tolerant design. Eligible patients will undergo standardized counseling and select their preferred treatment arm. The study aims to evaluate whether minimally invasive energy-based therapies offer superior postoperative pain relief and faster functional recovery compared to conventional hemorrhoidectomy

Participants needed: 60
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Chang Gung Memorial HospitalUpdated: Aug 7, 2026Locations: 1
Eligibility criteria

Diagnosed with Goligher Grade III internal hemorrhoids. [+5]

Other anorectal diseases (fistula, abscess, IBD, malignancy). [+3]

Status: Recruiting

PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study)

The goal of this clinical trial is to learn if the sacral erector spinae plane block can provide equal or better pain control than the pudendal nerve block in adults undergoing hemorrhoid surgery. The main question is: Which block offers more effective analgesia and faster recovery?

Participants needed: 64
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Andrea SaporitoUpdated: Mar 18, 2026Locations: 1
Eligibility criteria

Adults (≥18 years old) scheduled for elective excisional hemorrhoidectomy; [+3]

Pregnancy; [+7]