Initial Caries

2

Review clinical trials related to Initial Caries. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Early Detection of Initial Caries Using Fluorescent Starch Nano-particles Compared With Salivary Biomarkers

Dental caries is one of the most prevalent chronic oral diseases worldwide and remains a major public health concern. The disease begins with microscopic demineralization of enamel, which is reversible if diagnosed at an early stage. Therefore, early detection of carious lesions is essential to implement preventive and minimally invasive treatment strategies before irreversible tooth destruction occurs.

Participants needed: 60
Trial details
Age: 18-40Biological sex: AllType: InterventionalSponsor: Menoufia UniversityUpdated: Aug 12, 2026Locations: 1
Eligibility criteria

Cavitated carious lesions [+4]

Status: Recruiting

A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome

The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in teeth. This study aims to observe the changes in the International Caries Detection and Assessment System (ICDAS) scores, the concentration of salivary proteins, and cariogenic microbes, six months after the interventions. * Group A will get vitamin D supplements and oral hygiene instructions (OHI). * Group B will get vitamin D supplements, topical fluorides, and OHI. * Group C (Control), the vitamin D sufficient group will get topical fluorides and OHI.

Participants needed: 90
Trial details
Phase: Phase 4Age: 12-50Biological sex: AllType: InterventionalSponsor: Dow University of Health SciencesUpdated: Mar 11, 2025Locations: 1
Eligibility criteria

Patients of all genders and ages ranging from 12-50 years, having at least two t... [+1]

Patients who have heavy calculus, gingivitis, or periodontitis. [+5]