Perceived Stress

15

Review clinical trials related to Perceived Stress. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Effect of a Brief Self-Compassion Intervention on Nursing Students

Nursing students may experience considerable stress related to academic demands, clinical training, adaptation to university life, and concerns about professional competence. First-year nursing students may be particularly affected as they adjust to both university education and the nursing profession. Self-compassion refers to responding to personal difficulties, failures, or stressful experiences with kindness, understanding, and a balanced awareness rather than harsh self-criticism. Previous research suggests that self-compassion may support stress management and psychological well-being, and that self-compassion skills can be developed through structured interventions. This study will evaluate the effects of a brief self-compassion intervention among first-year nursing students. The intervention consists of two weekly, 90-minute face-to-face group sessions that include education and guided self-compassion practices. The study will examine whether the intervention is associated with changes in self-compassion, perceived stress, and mental well-being. Outcomes will be assessed at baseline, immediately after the intervention, and six weeks after completion of the intervention. The findings may provide information about the potential usefulness of a brief self-compassion intervention for supporting the psychological well-being of nursing students.

Participants needed: 160
Trial details
Age: 18-45Biological sex: AllType: InterventionalSponsor: Mersin UniversityUpdated: Oct 7, 2026Locations: 1
Eligibility criteria

First-year undergraduate nursing student. [+2]

Not being a first-year undergraduate nursing student. [+2]

Status: Not yet recruiting

A Persian AI-Based CBT Chatbot and Voice Analysis System for Managing Perceived Stress

This pilot randomized controlled trial aims to evaluate a Persian-language artificial intelligence (AI)-based cognitive behavioral therapy (CBT) chatbot designed to support adults in managing perceived stress. A total of 120 adults will be randomly assigned to one of three groups: an AI-based CBT chatbot intervention, active mental health educational content, or a waitlist control. The intervention period will last 14 days. The study will evaluate the feasibility, acceptability, safety, and preliminary effectiveness of the AI-based CBT chatbot for perceived stress management. As a separate research component, voice recordings will be collected from participants at baseline and at the end of the study. These recordings will be used solely as research data to train and evaluate an artificial intelligence model for stress detection. The voice-based model will not be used to guide, modify, personalize, or influence the study intervention, chatbot responses, participant allocation, or clinical decision-making during this trial.

Participants needed: 120
Trial details
Age: 18-45Biological sex: AllType: InterventionalSponsor: Hamid Reza MaratebUpdated: Sep 25, 2026Locations: 1
Eligibility criteria

Age between 18 and 45 years [+5]

Severe perceived stress at the initial screening assessment [+9]

Status: Recruiting

An Online Intuitive Eating Program for Pregnant Women With Obesity to Support Well-Being

The goal of this feasibility randomized controlled trial is to assess the feasibility, acceptability, and demand, as well as preliminary effects of an evidence-based Intuitive Eating (IE) intervention among pregnant women who have obesity. The main research questions are: RQ1: What is the feasibility (acceptability and demand) of implementing an Intuitive Eating Intervention among pregnant and postpartum women? RQ2: How does participation in the Pregnancy Intuitive Eating Intervention (PIE-I) impact key maternal health outcomes (i.e., gestational weight gain, intuitive eating behaviors, dietary quality, body image, and mental health) compared to a wait-list control? Researchers will compare the Pregnancy Intuitive Eating Intervention (PIE-I) intervention group with the wait-list control to see what impact the PIE-I has on maternal well-being. Participants randomized to the intervention group will complete the 8 week asynchronous IE intervention and have an opportunity to interview at the end of the study.

Participants needed: 80
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: San Diego State UniversityUpdated: Sep 15, 2026Locations: 2
Eligibility criteria

Age ≥18 years [+5]

Current or past diagnosis of an eating disorder (e.g., anorexia nervosa, bulimia... [+5]

Status: Not yet recruiting

Midwife-led Cognitive Behavioral Intervention for Perinatal Depression. Multisite RCT

Perinatal depression(PND), or depression during pregnancy and within one year following childbirth, is the most burdensome maternal mental illness. Women in low-income countries like Ethiopia have suffered from the disease. Perinatal depression(PND) carries several negative outcomes on women's mental health condition, their household functioning, workplace efficiency, and relationships with their children and families. It also has adverse outcomes on the developing fetus and neonatal health, such as intrauterine growth restriction, increased risk of underweight infants, and child cognitive and developmental delays. Mothers experiencing PND in Ethiopia remain underserved because stakeholders' primary attention is directed toward other competing maternal concerns such as pregnancy-related haemorrhage or pregnancy-induced hypertension. As a result, depressed perinatal women continue to suffer without adequate recognition or intervention. Furthermore, women with PND in this country face numerous barriers to care; pharmacological treatment is limited due to affordability issues, a shortage of prescribing experts, and accessibility challenges. Thus, to challenge the treatment gap in maternal mental health care for PND, Cognitive Behavioral Interventions (CBI) may be an alternative that could be delivered by relatively accessible professionals such as midwives. Although midwives play a critical role in maternal healthcare provision, the efficacy of supportive care for perinatal depression utilizing CBI techniques delivered by them remains limited. This approach may help to ensure women with PND receive both maternal and mental healthcare holistically and sustainably. This study aims to evaluate the effectiveness of midwife-led cognitive behavioral intervention delivered to women with PND in reducing depression, increasing social support, lowering stress, and measuring progress in cognitive restructuring, behavioral activation, and perceived problem-solving compared to usual care. The study will be conducted in three hospitals in the South Gondar zone, Ethiopia. It will include pregnant women in the third trimester who are experiencing depression, able to hear and speak the local ( Amharic) language, and willing to be part of the study. Women with severe medical conditions that limit their ability to participate in the intervention will not be included. Eligible participants will be randomized into an intervention and control group in a 1:1 ratio. Participants enrolled in the intervention group will receive cognitive behavioral intervention delivered by trained midwives, and also receive usual maternal care services. The control group will receive the standard usual care. The intervention contains seven sessions that start at 32 weeks of pregnancy and continue after childbirth. The first five sessions will be provided during pregnancy and the remaining two sessions after childbirth. Both antepartum and postpartum sessions will be provided weekly in groups ( 8-10 participants per group), delivered in a face-to-face format, for 45 to 50 min. The intervention strategies were formulated with the core principle of the cognitive behavioral model, and various strategies were used to contextualize it. The core content of each session was structured as a story-based example to capture and retain participants' attention and enhance clarity. Concepts were articulated using locally familiar and simple colloquial expressions. The behavioral activation techniques frequently practiced by Ethiopian women were incorporated to encourage engagement in routine activities. The intervention includes psychoeducation, group-based brainstorming, guided identification of negative thoughts, identification of cognitive distortions, and demonstration of techniques to replace negative with rational thoughts. For behavioral activation, activity scheduling and goal-setting techniques are incorporated to support engagement of participants in pleasant activities. Additionally, problem-solving will be supported to improve social interaction and enhance parenting practices. Participants' take-home assignments and daily mood follow-up charts will also be used as part of the intervention strategies. To evaluate the study effect, various outcome measurements will be conducted before the intervention, immediately after the intervention, and three months after the intervention.

Participants needed: 192
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: The Hong Kong Polytechnic UniversityUpdated: Sep 9, 2026Locations: 3
Eligibility criteria

Women aged 18 or more years. [+3]

EPDS score of ≥ 20. [+2]

Status: Not yet recruiting

Robot-Assisted Meditation for Older Adults With Cognitive Concerns

While traditional app-based mindfulness meditation programs relying solely on audio guidance have shown potential benefits for older adults, the programs often face challenges such as low engagement. Participants frequently report difficulties in maintaining focus during meditation sessions, which can limit its effectiveness in improving outcomes such as stress reduction and sleep quality. To address these limitations, this study examines whether a haptic robot that provides both tactile and audio guidance can enhance meditation. The robot's expansion and contraction movements help users pace and sustain rhythmic breathing, while gentle vibrations signal phase transitions without disrupting concentration. These haptic features are intended to anchor attention and support a more embodied practice. The study primarily seeks to answer the following questions: Does a haptic enabled meditation intervention reduce perceived stress in older adults living alone with subjective cognitive decline more effectively than an audio only mindfulness meditation guidance provided by a non-moving robot? To what extent does enhanced attentional anchoring mediate the intervention's effect on perceived stress in this population? By addressing these questions, the research aims to determine whether haptic enabled meditation technology can overcome common barriers to mindfulness practice among older adults and serve as an innovative tool to reduce perceived stress, and ultimately improve their sleep quality and physical, emotional, and cognitive well being.

Participants needed: 100
Trial details
Age: 65-80Biological sex: AllType: InterventionalSponsor: Johns Hopkins UniversityUpdated: Aug 31, 2026
Eligibility criteria

Participants have subjective cognitive decline, assessed using the Subjective Co...

Participants do not have dementia or mild cognitive impairment. [+1]

Status: Not yet recruiting

Gardening Activities, Stress, and Social Interaction Among University Students

This study is a quasi-experimental research project with a pretest-posttest control group design, structured to determine the effect of organized gardening activities on peer interaction, stress levels, and nature engagement behaviors among university students.The population of the research consists of students from the Vocational School of Health Services (VSHS) at Bingol University. The sample size, determined via G\*Power analysis (including a 20% anticipated drop-out rate), comprises a total of 100 volunteer students, divided into an intervention group (n = 50) and a control group (n = 50).The intervention group will participate in a structured program held twice weekly for 1 month (totaling 8 sessions, 60-90 minutes each) in the VSHS garden, encompassing soil preparation, paired seedling planting, group-oriented maintenance, and landscaping activities. The control group will maintain their routine campus life.Data will be collected using a Personal Information Form, the Perceived Self-Efficacy Scale (Coping with Stress), the University Life Scale (Peer Relations Subscale), and the Connectedness to Nature Scale. The data will be evaluated through homogeneity tests and parametric/non-parametric comparative analyses (t-tests, Wilcoxon, Mann-Whitney U).Contingency plans (Plan B)-such as indoor potted plant/terrarium workshops and buffer sample recruitment-are established to address adverse weather conditions, sample attrition, and seasonal risks.

Participants needed: 100
Trial details
Age: 18-25Biological sex: AllType: InterventionalSponsor: Ataturk UniversityUpdated: Aug 14, 2026
Eligibility criteria

Being an active undergraduate student at Bingol University Vocational School of... [+4]

Absence from more than 25% of the sessions (missing more than 2 sessions) during... [+1]

Status: Not yet recruiting

Mandala Coloring, Stress, and Anxiety

\*\*Abstract\*\* Although pregnancy is a physiological process, it also involves various risks that may threaten the health of both the mother and fetus. Complications arising in high-risk pregnancies and prolonged bed rest increase stress and anxiety levels in women, negatively affecting both physical and psychological well-being. Failure to recognize or appropriately manage these adverse conditions may lead to serious perinatal outcomes such as preterm birth, low birth weight, depression, and difficulties in mother-infant bonding, thereby creating an additional burden on both maternal-infant health and the healthcare system. This proposed project aims to examine the effect of mandala coloring activity on perceived stress and anxiety in women with high-risk pregnancies. The study will be conducted as a randomized controlled experimental study with a pretest-posttest design. The population of the study will consist of pregnant women hospitalized in the Obstetrics and Gynecology service of Kahramanmaraş Sütçü İmam University Health Practice and Research Hospital. Based on power analysis, with a significance level of α = 0.05 and statistical power of (1-β) = 0.80, at least 26 participants per group were required assuming a large effect size (Cohen's d ≈ 0.80). Considering potential sample loss, 30 participants were planned for each group, resulting in a total sample size of 60. Before data collection, ethics committee approval and institutional permission will be obtained. Data will be collected using the Personal Information Form, the Perceived Stress Scale in Risky Pregnancies Based on the Neuman Systems Model, and the State Anxiety Inventory. Pregnant women in the experimental group will participate in mandala coloring once daily for three consecutive days. Stress and anxiety levels will be assessed before and after the intervention using the relevant scales. In addition to descriptive statistical methods, appropriate statistical tests will be used according to normality assumptions. The methods specified in the project will be carried out by the principal investigator under the supervision of the advisor. The project is expected to demonstrate that mandala coloring is effective in reducing stress and anxiety in women with high-risk pregnancies. In line with the goals emphasized in Türkiye's 12th Development Plan regarding innovative healthcare practices and strengthening public health, the findings are expected to contribute to the protection of maternal and infant health and the promotion of psychological well-being. Furthermore, by supporting reductions in medication use, length of hospital stay, and healthcare costs, the project may contribute to the dissemination of cost-effective, accessible, and holistic care approaches within the healthcare system. Mandala coloring is an easily applicable, side-effect-free, and low-cost method that does not require special equipment, technical expertise, or a professional art therapist. In this respect, it represents a sustainable non-pharmacological intervention that can be easily implemented by nurses in both hospital settings and community-based healthcare services, with almost no training or material costs. Therefore, the findings of this project are expected to support not only individual-level psychological relaxation but also the development of cost-effective, innovative, and accessible care models in healthcare services. The project outcomes are also expected to strengthen the holistic care approach in nursing and promote the integration of non-pharmacological interventions into clinical protocols. The findings of the study will be published in scientific journals and presented at national and international congresses. In addition, this research will contribute to the literature and provide a basis for the development of more comprehensive future projects. One of the most important outcomes of this research is that it will enable an undergraduate student to gain experience in conducting research, interpreting results, and preparing for publication, thereby contributing to the training of qualified researchers in priority areas of our country.

Participants needed: 60
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Kahramanmaras Sutcu Imam UniversityUpdated: Jul 24, 2026
Eligibility criteria

Aged 18 years or older [+5]

Presence of a fetal anomaly or fetal distress [+5]

Status: Not yet recruiting

Fascial Yoga in Menopausal Women

Aim: The aim of this study is to evaluate the effects of a structured fascial yoga-based behavioral intervention on perceived stress, cognitive control, and cognitive flexibility in menopausal women. The study aims to determine whether a non-pharmacological and non-invasive behavioral intervention can support psychological and cognitive functioning and reduce perceived stress in menopausal women. Design: This study is designed as a randomized controlled, pretest-posttest experimental study with a post-intervention follow-up assessment. Eligible participants will be randomly assigned to either the intervention group or the control group receiving usual care. Outcomes will be assessed at baseline, immediately after the intervention, and at follow-up to evaluate both the immediate and sustained effects of the intervention. Method: A total of 60 menopausal women aged 45-65 years will be recruited from the menopause outpatient clinic and randomly assigned to either the intervention group or the control group. The intervention group will participate in a 12-week online fascial yoga program consisting of two 60-minute sessions per week. In this study, fascial yoga is defined as a fascia-focused, non-pharmacological, and non-invasive behavioral intervention that includes myofascial release techniques, breath regulation, body awareness, and basic yoga practices to support stress regulation and cognitive functioning. The program will include myofascial release techniques, basic yoga postures suitable for all physical fitness levels, and structured breathing exercises. All sessions will be conducted online in a group format, and no audio or video recordings will be taken. The control group will continue to receive routine outpatient care during the study period. After completion of the follow-up assessments, the fascial yoga program will be offered to participants in the control group upon request. Data will be collected at three time points: at baseline before the intervention, immediately after completion of the 12-week intervention, and at the follow-up assessment 8 weeks after the intervention. Perceived stress, cognitive control, and cognitive flexibility will be assessed using validated self-report questionnaires. Hypotheses: H1: Menopausal women participating in the fascial yoga intervention will show a significant reduction in perceived stress levels compared with the control group at post-intervention and follow-up assessments. H2: Menopausal women participating in the fascial yoga intervention will show a significant improvement in cognitive control and cognitive flexibility compared with the control group at post-intervention and follow-up assessments.

Participants needed: 60
Trial details
Age: 45-65Biological sex: FemaleType: InterventionalSponsor: Marmara UniversityUpdated: Jul 22, 2026
Eligibility criteria

Female participants aged 45-65 years [+2]

Current or past diagnosis of a psychiatric disorder or ongoing psychiatric treat... [+4]

Status: Recruiting

The COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine

Introduction. Switzerland, like most Western countries, faces a paradox: an ageing, multimorbid population needs general internal medicine (GIM) physicians more than ever, yet fewer young doctors choose - and stay in - the specialty. Career decisions during residency are intertwined with well-being, mental and physical health, and work-life balance, and distress in training has been associated with depression, burnout, attrition and poorer patient care. Longitudinal data following GIM residents across these domains, and linking them to actual career trajectories, are lacking. The COMET study establishes a multicentre prospective cohort of GIM residents to fill this gap. Methods and analysis. COMET is a prospective, open, multicentre cohort conducted in the departments of (general) internal medicine of Fribourg Hospital (HFR, four sites), Bern University Hospital (Inselspital) and Lausanne University Hospital (CHUV). All GIM residents providing direct patient care are eligible (≈334 residents; expected enrolment ≥267, assuming 80% participation). Participants complete an annual online survey (REDCap; French or German) at baseline and for at least four years, covering sociodemographics; job characteristics; career intentions and 24 factors for or against a GIM career; well-being (Physician Well-Being Index, Professional Fulfillment Index, quality of life, work-life balance); mental health (CES-D, Perceived Stress Scale, Maslach Burnout Inventory, Questionnaire of Cognitive and Affective Empathy); and physical health (step counts, physical activity, fatigue, sleep, healthcare utilisation). Primary endpoints are the longitudinal course of well-being and distress (PWBI, PFI, CES-D) and residents' career trajectory. Analyses combine descriptive statistics, mixed-effects and regression models, and comparisons with the population-based CoLaus\|PsyCoLaus cohort.

Participants needed: 800
Trial details
Biological sex: AllType: ObservationalSponsor: University of FribourgUpdated: Jul 16, 2026Locations: 3Duration: 5 Years
Eligibility criteria

Not listed

Status: Not yet recruiting

Psychological Resilience, Perceived Stress and Periodontal Status Among Bruxers

The present study aims to evaluate psychological resilience as a modifier of the relationship between perceived stress and periodontal status among bruxers. Given that both stress and inflammation share common neuroendocrine and immunological pathways, resilience may play a crucial role in buffering stress-induced periodontal breakdown. Understanding this relationship could shift periodontal management toward a biopsychosocial model, integrating psychological assessment and resilience enhancement with conventional non-surgical therapy. Such insights could help design personalized periodontal care strategies addressing both biological and psychological determinants of disease progression.

Participants needed: 75
Trial details
Age: 30-50Biological sex: AllType: ObservationalSponsor: Postgraduate Institute of Dental Sciences RohtakUpdated: Jun 2, 2026Locations: 1
Eligibility criteria

Patients with age group 30-50 years diagnosed with generalized periodontitis. [+3]

Systemic diseases that may affect periodontal disease progression or outcome of... [+5]

Status: Recruiting

Enjoying Affordable and Tasty Food Together

The goal of this pilot study is to examine the feasibility of a novel meal kit and nutrition education intervention among adults aged 40 years and older, who are lower income, and to evaluate the preliminary impact of the meal kit and nutrition education intervention on food insecurity, dietary quality, mental health, quality of life and cardiovascular risk factors compared with general nutrition education materials in this population. The main questions are: What is the acceptability and satisfaction with the meal kits and nutrition education intervention? What are the participation rates in the nutrition education program and the evaluation of the intervention? What is the impact of the intervention on food insecurity, dietary quality and cooking and food preparation self-efficacy compared with general nutrition education materials? What is the impact of the intervention of psychosocial health, quality of life and cardiometabolic outcomes compared with general nutrition education materials?

Participants needed: 120
Trial details
Age: 40+Biological sex: AllType: InterventionalSponsor: University of Massachusetts, LowellUpdated: May 5, 2026Locations: 1
Eligibility criteria

Adults aged 40 years and older. [+5]

Less than 40 years old [+10]

Status: Recruiting

A Pilot Study of RISE for Nurse Managers Retreat

The purpose of this study is to determine the feasibility and acceptability of the RISE for Nurse Managers retreat and its impact on occupational and psychological well-being indicators

Participants needed: 16
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: AdventHealthUpdated: Feb 19, 2026Locations: 1
Eligibility criteria

an employed AdventHealth Nurse Manager [+1]

a direct care RN, Nurse Director, Educator, and Executive [+1]

Status: Recruiting

Efficacy of Interactive Audio-based Mindfulness ChatGPT-Powered Intervention on Well-being

Brief mindfulness intervention is a short form is a form of short-duration practice, typically delivered for around 30 minutes or less (Howarth et al., 2019). It can be conducted in various formats, including a short breathing exercise or body scan (Palascha et al., 2021), and are increasingly offered through digital platforms, including app-based formats. Empirical evidence has examined the efficacy of brief mindfulness intervention and yielded mixed results. For some studies, positive effects were found, while some studies found no supporting evidence. Such inconsistencies may be due to the several current limitations of brief mindfulness intervention. Firstly, the duration of the intervention is too short. Given this brevity, these short practices may not offer the same immersion and depth that traditional mindfulness may offer. Secondly, most brief mindfulness utilised audio-based formats, which tend to be passive in nature and may not fully engage participants. Lastly, for brief mindfulness delivered through app-based platforms, these applications adopt a self-help approach, which may lower engagement and user commitment. Moreover, these applications also relied on audio guides which lacks the student-facilitator engagement found in traditional classes. To address the current limitations within the literature, a between-within-subjects experiment will be conducted where participants will be randomly assigned to one of the three conditions: (1) an interactive brief mindfulness breathing ChatGPT-powered intervention, (2) an interactive mind-wandering ChatGPT-powered control, or (3) a mindfulness breathing audio control. We hypothesise that the brief mindfulness breathing ChatGPT-powered intervention group will have significant improvements in well-being outcomes as compared to the other two control groups. By exploring the potential of an interactive ChatGPT-powered intervention, this study aims to understand its efficacy in improving well-being.

Participants needed: 210
Trial details
Age: 18-30Biological sex: AllType: InterventionalSponsor: Singapore Management UniversityUpdated: Jan 12, 2026Locations: 1
Eligibility criteria

Participants who are aged 18 to 30 (inclusive)

Not applicable

Status: Recruiting

Resilience Enhancement Training Program to Confront Nursing Students' Perceived Stress

The goal of this clinical trial is to assess if a resilience enhancement training program can help nursing students manage stress more effectively. The main question it aims to answer is: Does the program improve nursing students' resilience levels? Does the program lower nursing students' perceived stress levels? Researchers will compare students who receive the training during the semester with students who do not receive it until after the study is completed to see if the training has an effect. Participants will: 1. Complete questionnaires on resilience and stress before and after the training. 2. Attend a structured resilience enhancement training program for 10 weeks alongside their usual studies. 3. Be part of either the study group (receiving the training first) or the comparison group (receiving the training after study completion).

Participants needed: 90
Trial details
Biological sex: AllType: InterventionalSponsor: Ain Shams UniversityUpdated: Nov 17, 2025Locations: 2
Eligibility criteria

Nursing students enrolled in the Psychiatric and Mental Health Nursing (PMHN) co... [+1]

Students who decline participation or withdraw consent at any time. [+1]

Status: Not yet recruiting

Psychological Counseling Program for Alzheimer's Patients' Caregivers

Purpose: To investigate the effects of a psychological counseling program (PsychoCP) applied to caregivers of Alzheimer's patients on perceived stress, psychological well-being and care burden. Design: The study will be conducted in a pre-test post-test control group, randomized controlled experimental research design. Method: The study is planned to be carried out in Bağcılar Municipality Vefahâne Life Center, Antalya Alzheimer Patients and Patient Relatives Meeting Center and Osmaniye Family and Social Policies Directorate. The sample of the study will consist of 80 caregivers. They will be assigned to intervention (n=40) and control groups (n=40) by randomization. Hypotheses Hypothesis1: The perceived stress level of caregivers who received PsychoDP is lower than those who did not receive PsychoCP. Hypothesis2: The psychological well-being levels of caregivers who received PsychoDP are higher than those who did not receive PsychoCP. Hypothesis3: The care burden of caregivers who received PsychoDP is lower than those who did not receive PsychoCP.

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Aydan Akkurt YalçıntürkUpdated: Jan 1, 2025
Eligibility criteria

Providing informal care to an individual with mild or moderate Alzheimer's disea... [+7]

Not being able to understand questions and express ideas [+2]