Spastic Cerebral Palsy (sCP)

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Review clinical trials related to Spastic Cerebral Palsy (sCP). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Bilateral Asymmetry of Respiratory Muscle Activity During Breathing in Children With Spastic Cerebral Palsy

This observational cross-sectional study investigates the bilateral asymmetry of respiratory muscle activity during breathing in children with spastic cerebral palsy (CP). Children with CP often exhibit structural deformities, which may lead to impaired chest mobility and asymmetric respiratory function. The primary objective is to objectively evaluate the imbalance in the activation of bilateral respiratory muscles (intercostal, external oblique, and sternocleidomastoid) using non-invasive surface electromyography (sEMG). Muscle activity will be measured during resting breathing and active breathing tasks. The findings aim to provide clinical evidence for developing selective respiratory muscle training programs for this population.

Participants needed: 20
Trial details
Age: 4-12Biological sex: AllType: ObservationalSponsor: Sahmyook UniversityUpdated: Aug 20, 2026Locations: 1
Eligibility criteria

Children with Gross Motor Function Classification System (GMFCS) Level I or II [+2]

Children who have undergone orthopedic surgery of the spine or lower extremities... [+2]

Status: Not yet recruiting

tDCS and Bi-manual Training in Cerebral Palsy

Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function. Traditional therapies such as constraint-induced movement therapy (CIMT) and bimanual intensive training offer limited benefits. Pharmacologic treatments often produce behavioral side effects and do not address underlying neuro-plastic deficits. There is an unmet need for safe, effective, non-invasive interventions targeting motor recovery through cortical modulation.

Participants needed: 15
Trial details
Age: 6-17Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: May 7, 2026Locations: 1
Eligibility criteria

Children aged 6-17 years with unilateral spastic CP [+1]

Any other neurological disorders [+2]

Status: Recruiting

Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular Harm

A cross-sectional design study will be carried out to explore the morphological muscle properties and alterations in muscle composition on a macroscopic level in children with spastic cerebral palsy (CP). Muscle composition will be assessed using quantitative Magnetic Resonance Imaging (qMRI) and shear wave elastography (SWE), while macroscopic muscle size properties will be evaluated through 'Three-dimensional freehand ultrasound (3DfUS).

Participants needed: 51
Trial details
Age: 2-16Biological sex: AllType: ObservationalSponsor: Universitaire Ziekenhuizen KU LeuvenUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

Children (boys/girls) with congenital brain lesion, confirmed with neuro-imaging... [+4]

Presence of dyskinesia or ataxia [+9]

Status: Not yet recruiting

Virtual Reality Combined With Bobath Therapy for Spastic Cerebral Palsy

Spastic cerebral palsy is a common neurodevelopmental disorder characterized by increased muscle tone, impaired balance, and limitations in motor function, particularly in the lower limbs. Conventional rehabilitation approaches such as the Bobath technique are widely used to improve posture control and movement patterns; however, patient engagement and task variability may be limited. This randomized controlled trial aims to evaluate the effectiveness of virtual reality (VR) combined with Bobath therapy on lower limb muscle activity, balance, and gross motor function in patients with spastic cerebral palsy. Eligible participants will be randomly assigned to either a VR plus Bobath intervention group or a conventional Bobath therapy group. The intervention will be delivered over a 6-week period, with sessions conducted five times per week. Outcome measures, including surface electromyography (sEMG), center of pressure (COP) parameters, and the Gross Motor Function Measure-88 (GMFM-88), will be assessed before and after the intervention. This study seeks to provide evidence on whether integrating VR into conventional rehabilitation can improve functional outcomes in children with spastic cerebral palsy.

Participants needed: 30
Trial details
Age: 2-14Biological sex: AllType: InterventionalSponsor: Tongren Hongxin Kangxin Traditional Chinese Medicine Hospital, Guizhou ProvinceUpdated: Feb 6, 2026Locations: 1
Eligibility criteria

Aged 2 to 14 years at the time of enrollment. [+5]

Presence of severe cognitive impairment that prevents participation in the inter... [+4]

Status: Recruiting

Talocrural Mobilization With Movement in Spastic Cerebral Palsy

The aim of this randomized controlled trial is to find the effect of Mulligan's Mobilization with Movement of Talocrural joint in Cerebral Palsy Patients having spasticity on improving Ankle Range of Motion, improving balance and its effect on Gait speed.

Participants needed: 40
Trial details
Age: 8-18Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Feb 21, 2025Locations: 1
Eligibility criteria

Both genders [+6]

visual, hearing disorders [+3]

Status: Not yet recruiting

The Effects of Oral Facial Facilitation and Oral Motor Therapy in Dysphagia

The objective of this research is to investigate the impact of oral facial facilitation and oral motor therapy dysphagia in individuals with spastic cerebral palsy. Specifically, the study aims to: * Evaluate changes in dysphagia and severity following a regimen of oral motor therapy and oral facial facilitation. * Assess improvements in swallowing function, including ease of swallowing and reduction in dysphagia symptoms, after implementing oral motor therapy and oral facial facilitation.

Participants needed: 13
Trial details
Age: 3-7Biological sex: AllType: InterventionalSponsor: Kafrelsheikh UniversityUpdated: Jan 21, 2025
Eligibility criteria

1. Confirmed diagnosis of spastic cerebral palsy (CP) by a qualified medical pro...

1. Diagnosis of other neurological disorders or conditions that may affect swall...

Status: Recruiting

Rhythmic Stabilization Versus Ball Balancing

Spastic Cerebral Palsy (CP) is the leading cause of upper motor neuron syndrome (UMN) in children. The primary factors contributing to motor behavior disorders in these children are impairments in motor control and muscle strength. These impairments result in changes in muscle growth and hinder the development of motor skills, leading to reduced muscle force generation and decreased flexibility. Spastic cerebral palsy is the most prevalent type, affecting 77% of individuals with CP, and is caused by damage to the motor cortex and pyramidal tracts. The motor cortex is responsible for transmitting voluntary movement signals from the brain to the muscles. Characteristics of spastic cerebral palsy include stiff muscles (hypertonia), which can cause jerky and repetitive limb movements (spasticity). Additionally, individuals with CP often have difficulties in processing somatosensory and proprioceptive information. Proprioceptive training refers to interventions aimed at enhancing proprioceptive function to ultimately improve motor performance, a concept that has been explored in studies focused on sports injuries. In this study, we will utilize two proprioceptive exercises-rhythmic stabilization and ball balancing-to promote functional improvement in the upper extremities of children with spastic CP.

Participants needed: 36
Trial details
Age: 6-12Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Nov 5, 2024Locations: 1
Eligibility criteria

Spastic diplegic CP children age 6 to 12 years, [+4]

Children with any other neurological impairment [+1]