Tooth Extraction Site Healing

8

Review clinical trials related to Tooth Extraction Site Healing. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Volumetric Efficacy of Alveolar Ridge Preservation

The goal of this clinical trial is to compare the effectiveness of four post-extraction socket management approaches in preserving alveolar ridge dimensions following tooth extraction in adults requiring implant-supported rehabilitation in posterior regions. The main questions it aims to answer are: * Which treatment approach provides the greatest preservation of hard- and soft-tissue dimensions 12 weeks after tooth extraction? * Does the use of a dense polytetrafluoroethylene (d-PTFE) membrane improve alveolar ridge preservation compared with approaches that do not use a membrane? * Are there differences among the treatment groups regarding postoperative healing, complications, pain, and bone regeneration? Researchers will compare spontaneous socket healing, autologous blood clot with d-PTFE membrane, autologous blood clot with leukocyte- and platelet-rich fibrin (L-PRF), and autologous blood clot with L-PRF plus d-PTFE membrane to determine which approach provides the best preservation of alveolar ridge dimensions and tissue healing. Participants will: * Undergo tooth extraction and be randomly assigned to one of four treatment groups. * Receive clinical examinations, intraoral scans, photographs, and cone-beam computed tomography (CBCT) imaging at scheduled follow-up visits. * Complete assessments of postoperative pain and oral health-related quality of life. * Undergo implant placement 12 weeks after tooth extraction, including collection of a bone biopsy for histomorphometric analysis. * Attend follow-up visits to evaluate peri-implant tissue health, marginal bone stability, and implant success up to 24 months after implant loading.

Participants needed: 70
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Universidad del DesarrolloUpdated: Sep 10, 2026Locations: 1
Eligibility criteria

Adults aged 18 years or older. [+4]

Current treatment with bisphosphonates or systemic corticosteroids. [+6]

Status: Recruiting

Assessment of the Impact of Neobone® (Biphasic Calcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction

The goal of this randomized clinical trial is to assess whether BCP (Biphasic Calcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using BCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing. The main questions it aims to answer are: Does BCP improve ridge preservation compared with natural healing? Researchers will compare BCP grafted sockets to natural healing sockets to see if BCP better preserves ridge volume. Participants will: Have a tooth indicated for extraction. Be assigned to either BCP or natural healing. Undergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.

Participants needed: 30
Trial details
Phase: Early Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Egas Moniz - Cooperativa de Ensino Superior, CRLUpdated: Jun 11, 2026Locations: 1
Eligibility criteria

18 years or older [+2]

Presence of active infection or severe inflammation in the intervention zone [+6]

Status: Recruiting

Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction

The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing. The main questions it aims to answer are: Does β-TCP improve ridge preservation compared with natural healing? Researchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume. Participants will: Have a tooth indicated for extraction. Be assigned to either β-TCP or natural healing. Undergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.

Participants needed: 30
Trial details
Phase: Early Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Egas Moniz - Cooperativa de Ensino Superior, CRLUpdated: Jun 11, 2026Locations: 1
Eligibility criteria

18 years or older [+2]

Presence of active infection or severe inflammation in the intervention zone [+6]

Status: Recruiting

Socket Preservation Using Autogenous Dentin

Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.

Participants needed: 80
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: University of OstravaUpdated: May 27, 2026Locations: 1
Eligibility criteria

18-70 years [+4]

drug or alcohol abuse [+6]

Status: Not yet recruiting

Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers

The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.

Participants needed: 12
Trial details
Age: 18-75Biological sex: AllType: ObservationalSponsor: Marquette UniversityUpdated: Jan 28, 2026Locations: 1
Eligibility criteria

Adult patients (18-75 years) [+7]

Uncontrolled periodontal disease [+3]

Status: Recruiting

Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Participants needed: 160
Trial details
Age: 18-75Biological sex: AllType: ObservationalSponsor: Marquette UniversityUpdated: Nov 17, 2025Locations: 1
Eligibility criteria

Adult patients (18-75 years) [+5]

Smoking [+4]

Status: Recruiting

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser

Participants needed: 39
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Medical University of South CarolinaUpdated: Nov 12, 2025Locations: 1
Eligibility criteria

Participants who are ≥ 18 years old, [+4]

Untreated periodontal disease [+5]

Status: Not yet recruiting

Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid

Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.

Participants needed: 36
Trial details
Age: 6-10Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Oct 3, 2025Locations: 1
Eligibility criteria

Children aged from six to ten years. [+3]

Medically compromised children. [+2]