VSD

2

Review clinical trials related to VSD. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Follow-up After Percutaneous Device Closure of Ventricular Septal Defects

Ventricular septal defects (VSDs) are the most common congenital heart defects, accounting for 30-40% of congenital cardiac anomalies. They result from an abnormal opening in the interventricular septum, leading to left-to-right shunting. Clinical presentation depends on defect size and pulmonary vascular resistance, ranging from asymptomatic small defects to heart failure symptoms in infancy, with older children developing exercise intolerance or pulmonary hypertension. Although surgical closure has long been the standard treatment, percutaneous transcatheter device closure has emerged as a less invasive alternative for selected VSD types, particularly muscular and suitable perimembranous defects. This approach offers comparable efficacy with reduced morbidity and shorter hospital stays. This bicentric study aims to evaluate procedural success, complications, and short-term outcomes of percutaneous VSD closure in paediatric patients from Upper Egypt, providing essential data to guide clinical practice and quality improvement in tertiary cardiac centres.

Participants needed: 85
Trial details
Age: 6-18Biological sex: AllType: ObservationalSponsor: Assiut UniversityUpdated: Jul 20, 2026Duration: 6 Months
Eligibility criteria

Age: 6 months to 18 years [+9]

Active endocarditis or systemic infection [+8]

Status: Not yet recruiting

Bioabsorbable Occluder for Outlet VSD: Safety and Aortic Valve Effects

This study aims to evaluate the efficacy and safety of transcatheter bioabsorbable occluder closure in patients with outlet-type ventricular septal defect (outlet VSD), with a focus on assessing its impact on aortic valve function.

Participants needed: 50
Trial details
Age: 1+Biological sex: AllType: ObservationalSponsor: First Affiliated Hospital of Guangxi Medical UniversityUpdated: Jun 27, 2025Locations: 1Duration: 5 Years
Eligibility criteria

Age ≥1 year and weight ≥10 kg [+3]

Outlet VSD with a fibrous postero-inferior rim [+5]