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Condition / disease
Location
Status: Recruiting

Fortified Oral Rehydration Therapy for Pediatric Diarrhea

The goal of this clinical trial is to compare amino acid-fortified oral rehydration therapy (ORT) to the standard of care ORT in pediatric patients with acute gastroenteritis (AGE). The main questions it aims to answer are: * can amino acid-fortified ORT reduce the duration and severity of AGE compared to standard of care ORT? * can amino acid-fortified ORT increase the secretion of antimicrobial peptides in the gastrointestinal tract compared to standard of care ORT? Participants will be assigned to the experimental treatment (amino acid-fortified ORT) or the standard of care ORT and their disease severity, duration, and stool antimicrobial peptide content.

Participants needed: 72
Trial details
Phase: Phase 1, Phase 2Age: 6-5Biological sex: AllType: InterventionalSponsor: Paul A BreslinUpdated: Feb 12, 2026Locations: 1
Eligibility criteria

Between the ages of 6 months and 5 years. [+2]

Severe gastroenteritis with moderate to severe dehydration [+8]