Clinical trials

Nurses play an important role in providing vaccine information and supporting informed vaccination decisions. This study will evaluate a digital educational intervention designed for registered nurses in Quebec. The intervention will provide education about vaccination, including immunology, epidemiology, vaccine communication, motivational interviewing, and responding to vaccine misinformation. Registered nurses will be randomly assigned to either the intervention group or a control group. The study will examine whether the intervention improves vaccine confidence and vaccine communication compared with the control group. Participants will complete questionnaires before and after the intervention, with follow-up assessments at 3 and 6 months. The study will assess vaccine hesitancy and changes in vaccine-related knowledge, communication skills, and vaccination recommendation practices. The findings will help determine whether a digital educational intervention can support nurses in their vaccine-related communication and professional practice.

The goal of this clinical trial is to learn whether a supervised physical activity program can be successfully carried out for adults living with obesity and depression, and whether people are willing to take part in this kind of research. The main questions it aims to answer are: Can researchers recruit enough participants and keep them in the study? Will participants attend the physical activity sessions? Does physical activity change how depression symptoms are connected to each other over time? Researchers expect that the study procedures and the physical activity program will be feasible and acceptable, based on goals set before the study began. Researchers also expect that physical activity will weaken the connections between depression symptoms over time and will lower depression symptoms overall. This second idea will be tested more fully in a future, larger trial. Researchers will compare a supervised physical activity program to usual care to see whether the program can be delivered as planned and is acceptable to participants. Participants will: * Take part in a physical activity program led by a kinesiologist, twice a week for 9 weeks, or receive usual care plus information about physical activity and mental health support * Have a health check-up before and after the program * Answer short questions about their mood several times a day using a phone app * Take part in an interview after the program ends

The goal of this observational study is to validate medico-administrative algorithms that classify diabetes phenotypes (Type 1, Type 2, and Latent Autoimmune Diabetes in Adults - LADA) in a population-based cohort in Quebec, including children, adolescents, and young adults up to 40 years old with diagnosed diabetes. The main questions it aims to answer are: Can these algorithms accurately distinguish between Type 1, Type 2, and LADA across different age groups? What is the prevalence and incidence of each diabetes phenotype in Quebec? Participants will have their medical and administrative data analyzed, including data on medication usage and healthcare visits, to validate the accuracy of the algorithms. The study will involve comparing these algorithm-based classifications with clinical diagnoses or self-reported data to ensure reliability.