Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH

ConditionsPulmonary Arterial Hypertension (PAH)Pulmonary Vascular Disease Six-minute Walk Test NYHA High Altitude Effects High Altitude

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-80

SponsorSilvia Ulrich Somaini

About this trial

To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on six-minute walking distance and other scores in patients with pulmonary arterial hypertension PAH, who live permanently \>2600m.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients aged 18-80 years and of all genders

Permanent residence > 2600 m

Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines

Patients are stable on therapy

Disqualifiers

Age <18 years or >80 years

unstable condition

Patients who cannot follow the study investigations

Patient permanently living < 2600m.

Trial design

Design model

Single group

Treatments tested in this trial

Re-Ascent sea level to 2850m
Behavioral
After 7 days at sea level return/re-ascent to their usual living altitude at 2850m

Treatment groups

20 Participants

are divided into 1 treatment group

Group A: Six-minute walking distance 6MWD at sea level and after re-ascent at 2850mExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Six-minute walking distance after re-ascent to 2850m

Difference/change in six-minute walking distance 6MWD between sea level (after one-week stay) and day after re-ascent at 2850m in patients with pulmonary arterial hypertension

Time frame