To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently \>2600m.
Adults aged 18-80 years and of all genders
Permanent residence > 2600 m.
healthy: no self-perceived cardiopulmonary disease limiting daily activities
written informed consent to participate in the study.
Age <18 years or >80 years
Participants who cannot follow the study investigations
Participants permanently living < 2600m.
Participants who traveled and stayed overnight at altitudes <2000 m in the past 4 weeks.
Single group
Re-Ascent from sea level to 2850m
BehavioralAfter 7 days at sea level return/re-ascent to their usual living altitude at 2850m
Pulmonary resistance (sPAP/CO) after re-ascent to 2850m
Difference in sPAP/CO by echocardiography between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals
Tricuspid regurgitation velocity TRV after re-ascent to 2850m
Difference/change in tricuspid regurgitation velocity TRV between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals
Cardiac output CO after re-ascent to 2850m
Difference/change in cardiac output CO between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Tricuspid annular plan systolic excursion TAPSE after re-ascent to 2850m
Difference/change in tricuspid annular plan systolic excursion TAPSE between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Right ventricular strain after re-ascent to 2850m
Difference/change in right ventricular strain between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
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Silvia Ulrich Somaini
Lead sponsor
University of Zurich
Sponsor institution
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