Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age13-35
SponsorAl-Azhar University
About this trial
This study will evaluate the effect of locally applied Calcitriol on dental and skeletal changes during upper canine retraction. It is a split-mouth randomized clinical trial, where Calcitriol will be locally applied on one side of the maxilla, and the other side will serve as control.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Presence of class I malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.
Presence of class II malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.
Age range between 13 and 35 years to include both adolescent and adult patients suitable for orthodontic treatment.
Presence of permanent dentition.
Disqualifiers
History of chronic systemic disease.
Presence of active gingival or periodontal disease.
Known allergy or hypersensitivity to vitamin D.
Pregnancy or lactation.
Trial design
Design model
Parallel
Treatments tested in this trial
Calcitriol Delivery
DrugLocal delivery of Calcitriol (active form of vitamin D3) to one side of the maxillary canine area during orthodontic treatment. The aim is to assess its effect on dental and skeletal changes during canine retraction in a split-mouth design.
Treatment groups
22 Participants
are divided into 2 treatment groupsGroup A: Vitamin D Sufficient GroupExperimental treatment 1 intervention
Group B: Vitamin D Deficient GroupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Amount of maxillary canine retraction (mm) assessed on CBCT scans
The amount of maxillary canine movement will be assessed using cone-beam computed tomography (CBCT). Measurements will be expressed in millimeters
Time frame
T0: immediately before maxillary canine retraction. T1: after completion of canine retraction (approximately 4 months - 6 months)Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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