Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHospital H+ Queretaro
About this trial
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit. The main questions it aims to answer are:
* Does inhaled sedation reduce the total cost of care compared with intravenous propofol? * Does inhaled sedation reduce the duration of mechanical ventilation and ICU length of stay? * Are adverse events different between patients receiving inhaled sedation and those receiving intravenous propofol?
Researchers will compare patients who received inhaled sedation with patients who received intravenous propofol to see if inhaled sedation improves clinical outcomes and reduces overall costs.
Participants will:
* Be identified through review of electronic medical records * Be included if they are adults who received mechanical ventilation and were sedated with inhaled sedation or intravenous propofol * Contribute data on total costs of care, duration of mechanical ventilation, ICU length of stay, and adverse event
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 18 years or older
Admission to the intensive care unit at Hospital H+ Querétaro
Invasive mechanical ventilation for at least 24 hours
Receipt of inhaled sedation or continuous intravenous propofol sedation during ICU stay
Disqualifiers
Extracorporeal membrane oxygenation
Severe traumatic brain injury
Transfer to another hospital unit
Less than 24 hours of mechanical ventilation
Trial population
Adult critically ill patients admitted to the intensive care unit at Hospital H+ Querétaro who required invasive mechanical ventilation for at least 24 hours and received either inhaled sedation with isoflurane or continuous intravenous propofol sedation during ICU stay will be selected through retrospective review of electronic medical records
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Isoflurane
DrugIsoflurane administered as inhaled sedation through an anesthetic-conserving device in mechanically ventilated critically ill adult patients in the intensive care unit.
Propofol (Astra-Zeneca)
DrugPropofol administered as continuous intravenous sedation in mechanically ventilated critically ill adult patients in the intensive care unit.
Treatment groups
400 Participants
are divided into 2 treatment groupsGroup A: Inhaled Sedation Cohort1 intervention
Group B: Intravenous Propofol Cohort1 intervention
Trial outcomes
Primary outcomes
1
Total Cost of Care
Time frame
Through ICU discharge, an average of 7 daysLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: