The Role Intraoperative Salbutamol Inhaler in Preventing Atelectasis

Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-70
SponsorKing Abdullah University Hospital

About this trial

Atelectasis is considered a common complication in the perioperative period, especially following surgeries under general anesthesia. Postoperative atelectasis could occur anytime during the perioperative period from intraoperative period to 24 hours postoperative and contribute to a variety of other complications, including hypoxemia and pneumonia. In the literature, several methods were utilized to combat this phenomenon, therefore, we investigate the role of intraoperative salbutamol in reducing the incidence of atelectasis. It is well known that salbutamol could be an adjunctive bronchodilator medication used in the intraoperative anesthetic regimens.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

The study will include patients aged 18-70 years

American Society of Anesthesiologists (ASA) physical status of I or II

Will undergo thoracic, abdominal or spinal surgery

Disqualifiers

cardiac conditions other than hypertension like arrhythmia

previous cardiac surgeries and valvular heart diseases

Trial design

Design model

Parallel

Treatments tested in this trial

  • Salbutamol (Ventolin®)

    Drug

    -4 puffs of salbutamol (each puff = 100 µg, total dose 200-400 µg)

Treatment groups

80 Participants
are divided into 4 treatment groups
Group A: salbutamol group for diabetic patientsExperimental treatment 1 intervention
Group B: no intervention for diabeticNo intervention 0 interventions
Group C: salbutamol group for non-diabetic patientsExperimental treatment 1 intervention
Group D: no intervention for non-diabetic patientsNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Postoperative atelectasis (vital signs)

All patients will undergo a thorough medical history, appropriate physical examination, and relevant investigations according to their clinical needs. Particular attention will be given to vital signs, especially pulse oximetry.

Time frame
5 months
2

Postoperative atelectasis (x-ray)

All patients will undergo a chest X-ray to investigate for atelectasis.

Time frame
5 months
3

Postoperative atelectasis (blood gases)

Postoperatively blood gases will be assessed to investigate for atelectasis. This will be done through arterial blood gases sample at 24 hours postoperative.

Time frame
5 months

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

King Abdullah University Hospital

Lead sponsor

Jordan University of Science and Technology

Sponsor institution

Jordan University of Science and Technology

Collaborator

This trial is not recruiting at the moment. You can still explore other options: