The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (intervention) and healthy lifestyle (control) groups. The sleep extension is designed to increase participant's time in bed by 2 hours per night. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).
Age: 18-45 years old; equal numbers of men and women
Body mass index (BMI): 27.5-34.9 kg/m2
Sleep Habits: habitual self-reported average total sleep time (TST) <6.5 hours per night for prior 6 months
Clinically diagnosed sleep disorder or major psychiatric illness
Evidence of significant organ dysfunction or disease (e.g., heart disease, kidney disease)
Clinically diagnosed diabetes or fasting plasma glucose ≥126 mg/dL or HbA1c ≥6.5%
Use of prescription drugs or substances known to influence sleep or glucose metabolism, or anticoagulant medications.
Parallel
Sleep Extension Intervention
BehavioralSleep extension-based intervention focused on increasing time spent in bed by 2 hours per night by directly scheduling assigned bed and waketimes based on participant's individual schedules. Participants will receive weekly sleep tips and counseling on improving their sleep duration.
Total Plasma Ceramides
Total plasma ceramides will be measured by assessing plasma ceramides by targeted metabolomics.
Insulin Sensitivity
Insulin sensitivity will be measured by the glucose infusion rate per kg body weight during the hyperinsulinemic-euglycemic clamp.
Average (per week) nightly total sleep time (change from baseline)
Wrist-actigraphy
Average (per week) sleep satisfaction change from baseline
5 point likert scale on daily sleep log (1 = very good; 5 = very poor)
Average (per week) timing of food intake change from baseline
Time of day 50% of calories are consumed collected by picture based food diaries. Average per week will consist of two weekdays and one weekend day
Average (per week) daytime alertness change from baseline
5 point likert scale on daily sleep log (1= most alert; 5 = not alert at all)
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