Effects of Blood Gas Perturbations
ConditionHealthy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorSwiss Federal Institute of Technology
About this trial
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
healthy
non.smoking
normal lung function
BMI: 18.5-29.9 kg/m2
Disqualifiers
Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
Any metal or electronics inside of the body
Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
Trial design
Design model
Single group
Treatments tested in this trial
Gas perturbation
Other interventionParticipants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.
Treatment groups
16 Participants
are divided into 1 treatment groupGroup A: Gas perturbationsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Diaphragm contractility
Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.
Time frame
Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 secOther outcomes
1
Quadriceps contractility
Quadriceps contractility will be assess before, during and following the gas exposures and respiratory muscle contractions
Time frame
Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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