Effects of Flavonoid Foods on Carbonyl Stress
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-70
SponsorNorth Carolina Agriculture & Technical State University
About this trial
This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted LC-MS metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).
Eligibility criteria
Qualifiers
1. Age 25-70 years 2. BMI between 18 and 30 3. Have no known allergy to test food 4. have no known allergies to green tea, apples, blueberries, soy milk, and pineapples 5. Be not engaging in high-intensity exercise 6. Having blood and urine clinical tests in the normal range. 7. Be not taking antibiotics for six months 8. Be not currently taking medication
No taking any prescription drugs
If supplements were taken, flavonoid-enriched supplements (see list below) should be avoided.
No any drugs or supplements within three weeks of the experiment 9. Be nonsmoking 10. Have no alcoholic intoxication
Disqualifiers
1. Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders 2. Cancer patients
Currently diagnosed cancer patients will be excluded.
Medication free for >2 years could be considered.
Trial design
Treatments tested in this trial
- High-Flavonoid Diet
- Low-Flavonoid Diet
Treatment groups
36 Participants
are divided into 2 treatment groupsSponsors and collaborators
North Carolina Agriculture & Technical State University
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Source ClinicalTrials.gov