Lateral QL Block vs Intrathecal Morphine for Cesarean Section
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorOndokuz Mayıs University
About this trial
Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding. Although intrathecal morphine (ITM) is considered the gold standard for post-cesarean analgesia, its use is associated with opioid-related adverse effects. Ultrasound-guided lateral quadratus lumborum block (QLB-I) has emerged as a promising alternative. This randomized, double-blind, non-inferiority trial aims to compare the postoperative analgesic efficacy of lateral QLB-I with ITM. Secondary outcomes include postoperative opioid consumption, pain scores, opioid-related adverse effects, quality of recovery (ObsQoR-11T), and maternal satisfaction.
Eligibility criteria
Qualifiers
Women aged between 18 and 45 years.
Singleton term pregnancy (≥37 weeks of gestation).
American Society of Anesthesiologists (ASA) physical status II.
Scheduled to undergo elective cesarean delivery via a Pfannenstiel incision.
Disqualifiers
Known allergy or hypersensitivity to any of the study medications, including morphine, bupivacaine, or fentanyl.
Coagulopathy (international normalized ratio [INR] >1.5 or platelet count <100,000/mm³).
Current treatment with anticoagulant or antiplatelet agents (e.g., heparin, low-molecular-weight heparin, or aspirin >100 mg/day).
Infection, hematoma, or skin lesion at the planned block insertion site.
Trial design
Treatments tested in this trial
- Lateral Quadratus Lumborum Block
- ıv morphine PCA
- Intrathecal morphine
Treatment groups
56 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov