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Pericapsular Nerve Group and Lumbar Erector Spinae Plane Blocks for Geriatrics Undergoing Total Hip Arthroplasty

ConditionsPericapsular NerveLumbar Erector Spinae Plane BlocksGeriatricsTotal Hip ArthroplastyGeneral Anesthesia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age75+
SponsorTanta University

About this trial

This study will be conducted to evaluate the effect of pericapsular nerve group and erector spinae plane block as adjuvants to general anesthesia in geriatrics undergoing total hip arthroplasty.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged >75 years.

Both sexes.

American Society of Anesthesiologists (ASA) classification I-III.

Undergoing total hip arthroplasty under general anesthesia.

Disqualifiers

Patient refusal.

Body mass index (BMI) > 30 kg/m2.

Allergy to local anesthesia drugs.

Infection at the site of intervention.

Trial design

Design model

Parallel

Treatments tested in this trial

  • General anesthesia

    Drug

    Patients will receive general anesthesia.

  • Bupivacaine 0.5%

    Drug

    Patients will receive general anesthesia and erector spinae plane block.

  • Bupivacaine 0.5%

    Drug

    Patients will receive general anesthesia and erector spinae plane block with pericapsular nerve block.

Treatment groups

120 Participants
are divided into 3 treatment groups
Group A: General anesthesia groupExperimental treatment 1 intervention
Group B: Erector spinae plane block groupExperimental treatment 1 intervention
Group C: Pericapsular nerve block groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Mean sevoflurane MAC to achieve bispectral index (BIS) values (45-55)

Sevoflurane will be adjusted to maintain a steady state with a BIS value in the range of 45-55 and will be fixed through the study period

Time frame
Intraoperatively

Secondary outcomes

1

Pain degree

Each patient will be instructed about postoperative pain assessment with the Numerical Rating Scale (NRS). NRS (0 represents "no pain" while 10 represents "the worst pain imaginable").Pain intensity will be measured using a 10-point NRS at rest at 2, 4, 8, 12, 18, and 24 hours postoperatively.

Time frame
24 hours postoperatively
2

Fentanyl consumption.

Additional fentanyl bolus dosages of 1 µg/kg IV will be administered if heart rate or mean arterial blood pressure elevated more than 20% of the baseline (after exclusion of other causes than pain).

Time frame
Intraoperatively
3

Arterial blood pressure

MAP will be recorded pre-induction of anesthesia, post-induction of anesthesia and before performing of block, and every 15 min till the end of surgery. Intraoperative arterial blood pressure will be assessed. Hypotension (decrease in basal mean arterial blood pressure by 20%) will be treated with IV fluid.

Time frame
Till the end of surgery (up to 2 hours)
4

Heart rate

HR will be recorded pre-induction of anesthesia, post-induction of anesthesia and before performing of block, and every 15 min till the end of surgery.

Time frame
Till the end of surgery (up to 2 hours)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tanta University

Lead sponsor

Source ClinicalTrials.gov
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