The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.
The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Age ≥ 18 year
Able to understand written and spoken Danish language
PCS ≥20
Signed written informed consent form.
Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.
Individuals with diabetes requiring insulin treatment.
Pregnant or breastfeeding patients.
Patients with known allergies to the study drug.
Parallel
Dexamethasone
DrugPatients will receive either low dose (8mg) or high dose (1mg/kg)
Pain when coughing on the morning of first postoperative day.
The primary endpoint is pain when coughing on the first morning after surgery, measured on the NRS-scale (0-10; where 0 is no pain, and 10 is the worst possible pain).
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