"Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery"

ConditionsImpacted Mandibular Third Molar Postoperative Pain Trismus

Trial statusNot yet recruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18-55

SponsorHayat Abad Medical Complex, Peshawar

About this trial

This study aims to determine whether giving a single dose of dexamethasone before surgery can reduce pain and difficulty in opening the mouth after removal of an impacted lower wisdom tooth. Pain and limited mouth opening are common problems after this procedure and can affect eating, speaking, and daily activities.

A total of 268 patients aged 18 to 55 years who require surgical removal of an impacted mandibular third molar will be included. Participants will be randomly assigned to one of two groups. One group will receive a 4 mg dexamethasone injection under the gum before surgery, while the other group will not receive this medication. All patients will undergo the same surgical procedure and receive standard postoperative care.

Pain will be measured using a visual analogue scale, and mouth opening will be assessed using a standard measuring method. These outcomes will be recorded on the second and seventh days after surgery.

The results of this study will help determine whether preoperative dexamethasone is an effective and simple method to reduce postoperative discomfort and improve recovery after third molar surgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 18 to 55 years

Patients requiring surgical extraction of impacted mandibular third molars

Patients willing to provide informed consent

Disqualifiers

Patients with systemic diseases

Patients with periodontal disease

Pregnant or lactating women

Patients who have used antibiotics or anti-inflammatory drugs within the past 7 days

Trial design

Design model

Parallel

Treatments tested in this trial

Dexamethasone
Drug
A single 4 mg dose of dexamethasone is administered via submucosal injection at the surgical site following local anesthesia prior to extraction of the impacted mandibular third molar.
No intervention
Other intervention
Participants do not receive dexamethasone or any study drug. Standard surgical extraction of impacted mandibular third molars is performed, followed by routine postoperative care including analgesia.

Treatment groups

268 Participants

are divided into 2 treatment groups

Group A: Dexamethasone GroupExperimental treatment 2 interventions

Group B: No Drug Control GroupNo intervention 0 interventions

Trial outcomes

Primary outcomes

Postoperative Pain Assessed by Visual Analogue Scale (VAS)

Pain intensity will be measured using a 10-cm visual analogue scale (VAS), where 0 indicates no pain and 10 indicates worst possible pain. Scores will be recorded on postoperative day 2 and day 7.

Time frame

Postoperative Days 2 and 7

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Hayat Abad Medical Complex, Peshawar

Lead sponsor

Source ClinicalTrials.gov

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