Fixed-Mass Different Volumes Bupivacaine TAP Block After Cesarean

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age18+
SponsorCairo University

About this trial

Cesarean section is commonly associated with moderate to severe postoperative pain, which may delay mobilisation, impair breastfeeding, and affect mother-infant bonding. Although opioids, NSAIDs, and neuraxial techniques are commonly used for post-cesarean analgesia, their side effects have encouraged the use of peripheral nerve blocks such as the transversus abdominis plane block.

The TAP block is a fascial plane block that provides analgesia by depositing local anaesthetic between the internal oblique and transversus abdominis muscles. Its efficacy after cesarean section has been demonstrated, particularly when long-acting intrathecal opioids are not used. However, the optimal local anaesthetic volume and dose remain unclear. Since the TAP block depends on adequate spread of local anaesthetic, larger volumes may improve analgesic coverage, but increasing the dose may raise the risk of systemic toxicity.

Therefore, this study investigates whether using the same fixed mass of bupivacaine in two different volumes affects the analgesic efficacy of TAP block after cesarean section, hypothesising that the larger volume may provide better postoperative analgesia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

full-term parturients,

aged > 18 years

ASA physical status II

patients who are scheduled for elective CS with Pfannenstiel incisions under spinal anaesthesia.

Disqualifiers

Parturients with contraindications to spinal anaesthesia,

Having a scar or infection at the site of the block

BMI > 35 Kg/m2,

on chronic use of pain medications,

Trial design

Design model

Parallel

Treatments tested in this trial

  • Bupivacaine

    Drug

    Ultrasound-guided bilateral transversus abdominis plane block using 150 mg plain bupivacaine after cesarean section. The same total bupivacaine dose will be administered in two different volumes: 60 mL total volume, 30 mL per side

  • Bupivacaine

    Drug

    Ultrasound-guided bilateral transversus abdominis plane block using 150 mg plain bupivacaine after cesarean section. The same total bupivacaine dose will be administered in two different volumes: 120 mL total volume, 60 mL per side.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Fixed-mass, high-volume bupivacaine TAP blockExperimental treatment 1 intervention
Group B: Fixed-mass, low-volume bupivacaine TAP blockExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

total postoperative morphine consumption

Time frame
first 24 hours postoperatively

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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