Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorBrigham and Women's Hospital

About this trial

National guidelines recommend that older adults with cancer undergo a special health assessment before starting cancer treatment. This type of assessment evaluates physical function, nutrition, social support, psychological well-being, medical conditions (both cancer-related and non-cancer-related), and cognitive function. The results can help doctors make better treatment decisions and determine whether additional support services-such as nutrition counseling, physical therapy, or social work-would be beneficial. Even though these assessments are recommended, they are not typically used because they need to be performed by a specialist and can take over an hour to complete. Given these challenges, a 10-15-minute assessment called the Practical Geriatric Assessment (PGA) was recently developed. The PGA can be completed by any healthcare provider and helps identify older adults who may need extra support alongside their cancer treatment. While the PGA has the potential to make geriatric assessments more accessible, the investigators do not yet know whether patients will find it useful or easy to complete.

Additionally, it is unclear whether using the PGA will lead to more referrals for recommended supportive care services. This study aims to address these questions. The investigators will evaluate whether using the PGA impacts the number of patients referred to recommended supportive care services. Investigators will also evaluate how participants feel about completing the PGA, including how easy or difficult it is, and to assess the feasibility of implementing this survey on a larger scale. Finally, the investigators will use facial photographs and audio-visual data from the PGA to develop and evaluate artificial intelligence algorithm(s) to identify vulnerable patients who might benefit from additional supportive care services; namely, FaceAge, a validated deep learning model capable of estimating biological age from still facial images.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 65 years old at time of study enrollment.

Radiographically or pathologically confirmed stage I-II non-small cell lung cancer.

All patients must have undergone appropriate complete imaging of their cancer consistent with the standard of care.

Patient is expected to undergo stereotactic body radiation therapy (SBRT)

Disqualifiers

There are no exclusion criteria.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Practical Geriatric Assessment

    Other intervention

    The Practical Geriatric Assessment (PGA) is an abridged version of the Comprehensive Geriatric Assessment (CGA). This tool can be completed by any provider within 10-25 minutes while still capturing the key domains of the CGA. This screening tool, which is now recommended by American Society of Clinical Oncology (ASCO), the International Society for Geriatric Oncology (SIOG), and the Cancer \& Aging Research Group (CARG), has the potential capacity to delineate relevant baseline features in geriatric populations without creating undue provider burden.

Treatment groups

64 Participants
are divided into 2 treatment groups
Group A: PGA IMPLEMENTED IN NSCLC WITH SBRTExperimental treatment 1 intervention
Group B: SUPPORTIVE CARE WITHOUT PGA IN NSCLC WITH SBRTNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Rate of referral to recommended supportive care services

The primary endpoint for this study will be rate of referral to recommended supportive care services as compared to reported rates in historical cohorts, one month after PGA intervention.

Time frame
One-month post PGA Implementation

Secondary outcomes

1

Patient acceptance of PGA usage

The secondary endpoint for this study will be patient acceptance of PGA usage, as quantified by scores on the Response Burden Questionnaire (RBQ). Response Burden Questionnaire (RBQ). And to correlate domains of PGA with other measures of frailty/advanced age, including AI- based measures of biological including FaceAge, sit-to-stand test, and grip strength. 1. How well did these questions relate to your actual concerns? a. 0 (not at all related) to 10 (very related) 2. How well did these questions describe your health and well-being? a. 0 (not at all related) to 10 (very related) 3. How comfortable were you in answering these questions? a. 0 (not at all related) to 10 (very related) 4. How did you feel about the length of time to complete these questions? a. 1 (much too long), 2 (a bit too long), 3 (just right/no problem) 5. What questions seemed unimportant or repetitive: \_\_\_\_\_\_\_\_\_\_\_\_\_\_ 6. What additional information should we gather? \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_

Time frame
One-month post PGA Implementation

Other outcomes

Sponsors and contacts

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