Skin Microbial Ecology in Atopic Dermatitis

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age13+
SponsorUniversity of Rochester

About this trial

Everybody's skin has bacteria that normally lives on it. Previous research has shown that people with eczema (or atopic dermatitis \[AD\]) have much higher concentrations of a certain bacteria (S. aureus), especially when their disease is active but little is known about the role that this bacteria plays in psoriasis (i.e. disease severity, biomarkers and skin barrier function). The overarching purpose of this longitudinal study is to understand how the abundance of skin S. aureus (and several commensal bacteria) change as a consequence of standard of care treatment in the URMC dermatology clinics. Other assays and biospecimens will also be collected to address a number of questions.

Eligibility criteria

Qualifiers

≥13 to 65 years of age (inclusive) for PS, ≥13 for AD and NA, male or female

Optional Bx sub study - only adults (18-65 yrs; inclusive only)

Able to understand protocol and give consent

Able to keep clinic/study appointments and comply with study related procedures

Disqualifiers

Unwilling and/or unable to complete informed consent process

<13 or > 65 years of age for PS, >13 for AD and NA

AD subjects: disease without upper extremity, lower extremity, or trunk lesions

AD subjects: total disease severity less than moderate (EASI <12), depending on enrollment

Trial design

Treatments tested in this trial

  • AD subject visit sampling procedures
  • PS subject visit sampling procedures
  • Healthy control visit sampling procedures

Treatment groups

240 Participants
are divided into 3 treatment groups

Sponsors and collaborators