Health TrialsbyHealthPanel

The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain

ConditionsPostoperative PainPain ManagementRebound PainInterscalene Block
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorEskisehir Osmangazi University

About this trial

Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery. In postoperative pain management, single or continue interscalene brachial plexus blocks, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids administered as needed are commonly used as components of multimodal analgesia.

Rebound pain is defined as severe postoperative pain (VAS ≥ 7) occurring within the first 24 hours after resolution of the block. It is considered an adverse effect of regional anesthesia and typically develops 8-12 hours after a single-shot nerve block. Risk factors for rebound pain include pre-existing pain, female sex, younger age, bone surgery, lack of intraoperative dexamethasone administration, and inadequate analgesia.

The primary objective of this study is to evaluate the effect of intravenous dexketoprofen administered during the postoperative period on the incidence and severity of rebound pain in patients undergoing shoulder surgery with interscalene brachial plexus block

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Crossover

Treatments tested in this trial

  • ISB + paracetamol IV 3*1

    Drug

    ISB + paracetamol IV 3\*1

  • ISB+ paracetamol IV 3*1 +deksketoprofen IV 2*1

    Drug

    ISB+ paracetamol IV 3\*1 +deksketoprofen IV 2\*1. 25 miligram of dexketroprofen

Treatment groups

66 Participants
are divided into 2 treatment groups
Group A: Group KPlacebo comparator 1 intervention
Group B: Group DActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Effect of intravenous dexketoprofen administered during the postoperative period on the severity and incidence of rebound pain

Rebound pain score(VAS ≥ 7) and incidence

Time frame
24 hours

Secondary outcomes

1

Total opioid consumption

Total morphine patient control analgesia prepared 0.5 mg / ml. PCA 1 mg bolus dose will be delivered with 10 min lock-out time. Follow up morphine consumption at postoperative 24 hours

Time frame
24 hours
2

Visual analog Scale

Visual analog scale at rest and movement (0 (no pain)-10 (unbearable pain))

Time frame
24 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Eskisehir Osmangazi University

Lead sponsor

Source ClinicalTrials.gov
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