Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-75
SponsorCairo University

About this trial

This study is aiming to assess effect of hypertonic saline 5% in comparison to dextrose 20% on pain ,inter-insical opening and movements of jaw in painful cases of disc displacement with reduction

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

pain.

audible clicking.

mandibular deviation on opening.

Failure of conservative treatment

Disqualifiers

The clinical or radiographic signs of disc displacement without reduction, osteoarthritis, or articular bony changes.

Previous TMJ surgery, arthrocentesis, , or the presence of any systemic disease that would affect the TMJ anatomy or mechanical function.

A history of allergic reactions to any components of the injectable solution.

Infection of the affected joint and pre-auricular area.

Trial design

Design model

Parallel

Treatments tested in this trial

  • hypertonic saline 5% sodium chloride

    Other intervention

    Hypertonic saline acts as an analgesic by alleviating nociceptive pain from inflamed tissues, which may include bone, connective tissue , synovium , or a combination of these Hypertonic saline results in safe and remarkable outcomes on knee pain, stiffness and function compared with intra-articular dextrose injection

  • hypertonic dextrose 20%

    Other intervention

    A recent study showed the sensorineural analgesic effect of 5% dextrose prolotherapy in the treatment of chronic low back pain ,Therefore, the mechanism of action for dextrose prolotherapy is hypothesized to work through reducing peripheral sensitization and targeting structural dysfunction

Treatment groups

20 Participants
are divided into 2 treatment groups
Group A: painful cases with disc displacement with reductionActive comparator 0 interventions
Group B: painful cases of disc displacement with reductionExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Severity of pain

severity of pain is measured by Visual analog scale (VAS) From (0-10) Where 0: no pain 10: worst pain

Time frame
baseline and at 6 months

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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