Perioperative Analgesia

9

Review clinical trials related to Perioperative Analgesia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Ultrasound-Guided Parasternal/Rectus Sheath Block vs Erector Spinae Plane Block for Pain Control in Cardiac Surgery

The researchers are working to improve recovery after heart surgery by reducing reliance on opioids. Newer regional anesthesia techniques can provide strong pain relief with fewer risks, but the choice of method depends on each patient's condition, medications, and surgical plan

Participants needed: 50
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: National Cancer Institute, EgyptUpdated: Jul 13, 2026
Eligibility criteria

Both sexes, [+3]

Patients with global hypokinesia [+6]

Status: Recruiting

Adding Dexmedetomidine Versus Ketamine to Bupivacaine in Fluoroscopy Guided Caudal Analgesia for Lumbosacral Surgeries

This study will evaluate the effect of adding dexmedetomidine to bupivacaine compared to ketamine in the caudal block on perioperative analgesia in patients undergoing lumbosacral surgeries under general anesthesia.

Participants needed: 72
Trial details
Phase: Phase 3Age: 21-60Biological sex: AllType: InterventionalSponsor: Ain Shams UniversityUpdated: May 7, 2026Locations: 1
Eligibility criteria

Age 21-60 years. [+3]

Declining to give written informed consent or patients with significant cognitiv... [+4]

Status: Not yet recruiting

From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma

To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.

Participants needed: 150
Trial details
Age: 18-50Biological sex: AllType: ObservationalSponsor: Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)Updated: Mar 17, 2026Locations: 1Duration: 6 Weeks
Eligibility criteria

age ≥18 years [+5]

age <18 years [+4]

Status: Not yet recruiting

Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty

The Pericapsular Nerve Group (PENG) block is an effective method for postoperative pain management in patients undergoing primary total hip arthroplasty (THA) via a posterolateral approach. The application of this technique reduces postoperative opioid requirements, thereby limiting the risk of adverse effects associated with systemic opioid administration. Effective pain control and a reduced incidence of side effects may translate into higher patient satisfaction and a decreased length of hospital stay (LOS). The PENG block serves as an effective component of multimodal analgesia and may provide an alternative to intrathecal morphine in patients undergoing primary total hip arthroplasty via a posterolateral approach, where the primary anesthetic technique is spinal anesthesia with hyperbaric bupivacaine. Objectives 1. To evaluate the efficacy of the PENG block in postoperative pain control and compare its effectiveness with intrathecal morphine administration. 2. To assess the impact of the PENG block on postoperative opioid consumption in comparison to analgesia achieved via intrathecal morphine. 3. To analyze the incidence of selected adverse effects associated with systemic opioid administration in patients receiving a PENG block versus those in the intrathecal morphine group. 4. To evaluate patient satisfaction levels regarding postoperative pain management across the different analgesic modalities. 5. To analyze the correlation between the type of analgesia employed and the duration of hospitalization.

Participants needed: 180
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Medical University of GdanskUpdated: Mar 4, 2026
Eligibility criteria

Informed, written consent for study participation. [+6]

Absence of informed consent. [+9]

Status: Recruiting

Ultrasound-Guided External Oblique Intercostal Plane Block Versus Subcostal Transversus Abdominis Plane Block For Perioperative Analgesia in Laparoscopic Sleeve Gastrectomy

This study aims to compare the analgesic efficacy, duration of analgesia, and overall opioid consumption between the external oblique intercostal plane (EOIP) block and subcostal transversus abdominis plane (TAP) block in patients undergoing laparoscopic sleeve gastrectomy.

Participants needed: 70
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Benha UniversityUpdated: Jan 26, 2026Locations: 1
Eligibility criteria

Age from 18 to 65 years. [+5]

Patient refusal. [+6]

Status: Recruiting

Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy

This study aims to compare the analgesic effect of retro superior costotransverse ligament space block vs erector spinae plane block to Achieve high-quality perioperative opioid-sparing effect and postoperative analgesia after laparoscopic cholecystectomy with optimum hemodynamic stability and high patient and surgeon satisfaction

Participants needed: 80
Trial details
Age: 21-64Biological sex: AllType: InterventionalSponsor: Zagazig UniversityUpdated: Dec 12, 2025Locations: 1
Eligibility criteria

patient acceptance [+6]

Known hypersensitivity to lidocaine or bupivacaine. [+2]

Status: Recruiting

Perioperative Analgesia Modes in Minimally Invasive Esophagectomy

This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.

Participants needed: 102
Trial details
Phase: Phase 2, Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Cancer Institute and Hospital, Chinese Academy of Medical SciencesUpdated: Mar 20, 2025Locations: 1
Eligibility criteria

18-75 years; [+2]

Has a history of cholecystitis or urolithiasis within 3 months; [+9]

Status: Recruiting

Combined Ultrasound Guided Bilateral Rectus Sheath and Erector Spinae Plain Blocks Versus Erector Spinae Plain Block for Intra and Postoperative Analgesia in Elective Abdominoplastic Surgeries. a Randomized Controlled Double Blinded Trial.

The goal of this clinical trail is to determine if bilateral erector spinae plane block alone can provide good perioperative analgesia for abdominoplastic surgery patients or it is better to give combined bilateral rectus sheath and erector spinae plane blocks to achieve effective intraoperative and postoperative analgesia with minimal morphine consumption in such operations in which there is an extensive surgical dissection and a high risk of respiratory problems.

Participants needed: 40
Trial details
Age: 21-60Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jan 9, 2025Locations: 1
Eligibility criteria

patients Age from 21 to 60 years ,Male and female patients ,ASA I, II patients s...

Patient refusal, Age less than 21 and above 60 years old, ASA III, IV patients.,...

Status: Not yet recruiting

Fascia Iliaca Compartment Block and Tramadol for Analgesia in Hip Fracture

Hip fractures are a growing public health concern globally due to the aging population, with high incidence and significant mortality rates one year post-fracture. Effective pain management is critical to improving outcomes and accelerating recovery. Tramadol, a widely used intravenous analgesic, has dual opioid and non-opioid mechanisms but is associated with side effects, such as nausea, dizziness, and respiratory depression, necessitating careful monitoring in hip fracture patients. The supra-inguinal fascia iliaca compartment block (SiFICB) offers a promising alternative, targeting key nerves to achieve effective analgesia through ultrasound-guided delivery of local anesthetics. SiFICB minimizes side effects and improves pain control by accurately blocking the femoral, lateral femoral cutaneous, and obturator nerves. While its postoperative benefits are well-documented, its efficacy in managing preoperative pain from hip fractures remains underexplored. This study hypothesizes that ultrasound-guided SiFICB provides superior perioperative analgesia compared to intravenous tramadol. A prospective randomized controlled trial will evaluate the analgesic efficacy of SiFICB, using the numerical rating scale (NRS) to assess pain, aiming to improve the management of hip fracture-related pain and patient outcomes.

Participants needed: 240
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: West China HospitalUpdated: Dec 11, 2024Locations: 1
Eligibility criteria

Patients with a confirmed diagnosis of hip fracture [+2]

Allergic to tramadol or ropivacaine [+2]