Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH

ConditionsPulmonary Arterial Hypertension (PAH)Pulmonary Vascular Disease Polygraphy Sleep Sleep Disordered Breathing (SDB)High Altitude Effects High Altitude

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-80

SponsorSilvia Ulrich Somaini

About this trial

To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in patients with pulmonary arterial hypertension PAH, who live permanently \>2600m.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients aged 18-80 years and of all genders

Permanent residence > 2600 m

Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines

Patients are stable on therapy

Disqualifiers

Age <18 years or >80 years

unstable condition

Patients who cannot follow the study investigations

Patient permanently living < 2600m.

Trial design

Design model

Single group

Treatments tested in this trial

Descent to sea level
Behavioral
Descent from 2850m to sea level with a stay for 7 days and re-ascent back to 2850m

Treatment groups

20 Participants

are divided into 1 treatment group

Group A: Sleep-parameters at 2850m and at sea levelExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Mean nocturnal SpO2 after 7 days at sea level

Difference in mean nocturnal SpO2 between 2850m and Night 7 at sea level in patients with pulmonary arterial hypertension

Time frame